The interstitial nuclei of the human anterior hypothalamus: An investigation of variation with sex, sexual orientation, and HIV status
The interstitial nuclei of the human anterior hypothalamus: An investigation of variation with sex, sexual orientation, and HIV status
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DOI：
10.1006/hbeh.2001.1680
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发表时间：
2001-09-01
影响因子：
3.5
通讯作者：
Jones, LB
中科院分区：
文献类型：
--
作者：
Byne, W;Tobet, S;Jones, LB
人下丘脑前部的间质核（INAH 1 -4）被认为与大鼠视前区的性二形核同源。其中三个核团（INAH 1 -3）的体积性别二态性已被描述，并且据报道同性恋男性的INAH 3比异性恋男性的更小。目前的研究测量了34名假定异性恋男性（24名HIV-和10名HIV+），34名假定异性恋女性（25名HIV-和9名HIV+）和14名HIV+同性恋男性尸检材料中Nissl染色冠状切片的INAH。HIV感染状况显著影响INAH 1的数量（HIV阳性异性恋男性和女性比HIV阴性个体高8%），但对其他INAH没有影响。INAH 3含有显着更多的神经元，并占据了更大的体积在假定的异性恋男性比女性。对于任何其他INAH，未检测到体积的性别差异。在任何INAH中均未观察到神经元大小或密度的性别差异。虽然INAH 3在同性恋男性中占据的体积比异性恋男性小，但基于性取向的核内神经元数量没有差异。(C)北京：科学出版社.
The interstitial nuclei of the human anterior hypothalamus (INAH1-4) have been considered candidates for homology with the sexually dimorphic nucleus of the preoptic area of the rat. Volumetric sexual dimorphism has been described for three of these nuclei (INAH1-3), and INAH3 has been reported to be smaller in homosexual than heterosexual men. The current study measured the INAH in Nissl-stained coronal sections in autopsy material from 34 presumed heterosexual men (24 HIV- and 10 HIV+), 34 presumed heterosexual women (25 HIV- and 9 HIV+), and 14 HIV+ homosexual men. HIV status significantly influenced the volume of INAH1 (8% larger in HIV+ heterosexual men and women relative to HIV- individuals), but no other INAH. INAH3 contained significantly more neurons and occupied a greater volume in presumed heterosexual males than females. No sex difference in volume was detected for any other INAH. No sexual variation in neuronal size or density was observed in any INAH. Although there was a trend for INAH3 to occupy a smaller volume in homosexual men than in heterosexual men, there was no difference in the number of neurons within the nucleus based on sexual orientation. (C) 2001 Academic Press.