NTD prevalences in central California before and after folic acid fortification
NTD prevalences in central California before and after folic acid fortification
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DOI：
10.1002/bdra.20466
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发表时间：
2008-08-01
影响因子：
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通讯作者：
Shaw, Gary M.
中科院分区：
文献类型：
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作者：
Chen, Brian H.;Carmichael, Suzan L.;Shaw, Gary M.
背景：在许多地区，在叶酸强化之前，NTD的患病率已经在下降。这项研究调查了在加利福尼亚州选定的县中，防御工事前(1989-1996年)NTD流行率是否持续到防御工事后时期(1998-2003年)。方法：这项以人群为基础的研究使用了从医疗记录中主动确定的生命统计数据和出生缺陷登记数据。研究人群包括1989年至2003年在加利福尼亚州中部各县出生的所有活产和死产。病例包括在同一时间段内患有NTDS的分娩。结果：在所有NTDS的组合中，斜率显示NTD患病率在强化前每年每10万名产妇下降7.5例(斜率：-7.5；95%可信区间：-12.4，-2.5)，而强化后NTD患病率不再下降。两个斜坡的差异比较显示，加固后的斜坡每年每10万次接生比加固前的斜坡多12.6例(95%可信区间：2.6，22.6)。结论：在实施叶酸强化后，加利福尼亚州中部的NTD年患病率并没有继续下降。
BACKGROUND: In many regions, NTD prevalences were already declining prior to folic acid fortification. This Study examined whether the declining prefortification (1989-1996) NTD prevalences continued into the postfortification period (1998-2003) in selected California counties. METHODS: This population-based study used vital statistics data and birth defects registry data that v,,ere actively ascertained from medical records. The study population included all live births and stillbirths delivered in central California counties from 1989 to 2003. Cases included deliveries with NTDs during the same time period. RESULTS: For all NTDs combined, the slopes indicated that NTD prevalence was decreasing by 7.5 (slope: -7.5; 95% CI: -12.4, -2.5) cases per 100,000 deliveries per year before fortification, whereas NTD prevalence was no longer decreasing after fortification. Comparison of the difference in the two slopes indicated that the postfortification slope exceeded the prefortification slope by 12.6 (95% CI: 2.6, 22.6) cases per 100,000 deliveries per year. CONCLUSIONS: Annual NTD prevalences in central California did not continue to decrease after implementation of folic acid fortification.