Design of miniaturized illumination for transvaginal co-registered photoacoustic and ultrasound imaging
Design of miniaturized illumination for transvaginal co-registered photoacoustic and ultrasound imaging
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DOI：
10.1364/boe.5.003074
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发表时间：
2014-09-01
影响因子：
3.4
通讯作者：
Zhu, Quing
中科院分区：
文献类型：
--
作者：
Salehi, Hassan S.;Wang, Tianheng;Zhu, Quing
已经证明了用于紧凑的共配准光声/超声经阴道探头的基于透镜阵列的照明设计。透镜阵列由四个柱面透镜组成，它们将激光束耦合到四个1 mm芯多模光纤中，光耦合效率接近87%。通过使用Zemax模拟透镜和激光束轮廓来研究我们的透镜阵列的可行性。组织表面上的激光能量密度通过实验测量，并且低于美国国家标准协会（ANSI）的安全限值。利用多波长光声测量技术，在活体条件下获得了小鼠肿瘤组织中血红蛋白氧饱和度（sO（2））的空间分布。此外，良性和恶性卵巢离体成像和组织学评价。共配准图像清楚地显示了不同的血管模式。这些结果突出了我们的系统用于卵巢组织的非侵入性光声和超声成像以及癌症检测和诊断的临床潜力。(C)2014年美国光学学会
A novel lens-array based illumination design for a compact co-registered photoacoustic/ultrasound transvaginal probe has been demonstrated. The lens array consists of four cylindrical lenses that couple the laser beams into four 1-mm-core multi-mode optical fibers with optical coupling efficiency of similar to 87%. The feasibility of our lens array was investigated by simulating the lenses and laser beam profiles using Zemax. The laser fluence on the tissue surface was experimentally measured and was below the American National Standards Institute (ANSI) safety limit. Spatial distribution of hemoglobin oxygen saturation (sO(2)) of a mouse tumor was obtained in vivo using photoacoustic measurements at multiple wavelengths. Furthermore, benign and malignant ovaries were imaged ex vivo and evaluated histologically. The co-registered images clearly showed different patterns of blood vasculature. These results highlight the clinical potential of our system for noninvasive photoacoustic and ultrasound imaging of ovarian tissue and cancer detection and diagnosis. (C) 2014 Optical Society of America