Myocardial progenitors in the pharyngeal regions migrate to distinct conotruncal regions
Myocardial progenitors in the pharyngeal regions migrate to distinct conotruncal regions
复制标题
咽部的心肌祖细胞迁移到不同的圆锥干区域
DOI：
10.1002/dvdy.23714
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Nakajima Y
中科院分区：
文献类型：
--
作者：
Takahashi M;Terasako Y;Yanagawa N;Kai M;Yamagishi T;Nakajima Y
背景：流出道（OFT）的心脏祖细胞位于咽部区域的内脏中胚层和中胚层核心，分别被定义为次级和前部心脏区域（SHF和AHF），结果：使用鸡胚，我们在第14阶段将荧光染料注入SHF或AHF，并在第31阶段检查标记细胞的目的地。在OFT左背侧的心肌中发现了来自右侧SHF的标记细胞，在OFT右腹侧检测到来自左侧SHF的细胞。标记细胞从右和左AHF迁移到区域的腹侧壁的OFT接近主动脉瓣和肺动脉瓣，either.Conclusion：这些观察表明，心肌祖细胞从SHF和AHF有助于不同的圆锥动脉干区域和细胞从SHF迁移旋转，而细胞从AHF迁移在一个非旋转的方式。Developmental Dynamics 241：284-293，2012.© 2011 Wiley Periodicals，Inc.
Background:The cardiac progenitor cells for the outflow tract (OFT) reside in the visceral mesoderm and mesodermal core of the pharyngeal region, which are defined as the secondary and anterior heart fields (SHF and AHF), respectively.Results:Using chick embryos, we injected fluorescent‐dye into the SHF or AHF at stage 14, and the destinations of the labeled cells were examined at stage 31. Labeled cells from the right SHF were found in the myocardium on the left dorsal side of the OFT, and cells from the left SHF were detected on the right ventral side of the OFT. Labeled cells from the right and left AHF migrated to regions of the ventral wall of the OFT close to the aortic and pulmonary valves, respectively.Conclusion:These observations indicate that myocardial progenitors from the SHF and AHF contribute to distinct conotruncal regions and that cells from the SHF migrate rotationally while cells from the AHF migrate in a non‐rotational manner. Developmental Dynamics 241:284–293, 2012. © 2011 Wiley Periodicals, Inc.