Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats
Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats
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DOI：
10.1016/s0006-8993(00)03305-9
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发表时间：
2001-03-02
期刊：
影响因子：
2.9
通讯作者：
Myers, D
中科院分区：
文献类型：
--
作者：
Greenwood-Van Meerveld, B;Gibson, M;Myers, D
肠易激综合征（IBS）患者的焦虑发作通常与内脏疼痛的发作或加剧有关。中央杏仁核（CeA）是参与焦虑表达的关键边缘结构，也是调节自主神经和内脏对压力反应的主要部位。先前的实验表明，糖皮质激素可以直接作用于脑胶质瘤，增加大鼠的焦虑水平。因此，本研究的目的是通过测量大鼠对结直肠扩张的内脏运动反应来检查皮质酮立体定向递送至脑区对内脏过敏发展的影响。将皮质酮立体定向递送至 CeA 会增加焦虑指数并产生过敏性结肠，如 F344 大鼠品系对结直肠扩张的过度内脏运动反应所证明的那样。我们的研究结果表明，通过用皮质酮操纵杏仁核功能来调节焦虑，可通过 CeA 的下行神经元通路诱导结肠过敏。 (C) 2001 Elsevier Science B.V. 保留所有权利。
Episodes of anxiety are often associated with the onset or exacerbation of visceral pain in patients with irritable bowel syndrome (IBS). The central amygdaloid nucleus (CeA) is a key limbic structure involved in the expression of anxiety as well as a major site for regulating autonomic and visceral responses to stress. Previous experiments have shown that glucocorticoids can act directly at the CeA to increase the level of anxiety in rats. Therefore, the goal of this study was to examine the effect of stereotaxic delivery of corticosterone into the CeA on the development of visceral hypersensitivity by measuring visceromotor response to colorectal distention in rats. Stereotaxic delivery of corticosterone to the CeA increases indices of anxiety and produces a hypersensitive colon as demonstrated by an exaggerated visceromotor response to colorectal distention in the F344 rat strain. Our findings suggest that modulation of anxiety by manipulating amygdala function with corticosterone induced colonic hypersensitivity via descending neuronal pathways from the CeA. (C) 2001 Elsevier Science B.V. All rights reserved.