Alcohol, smoking and the risk of premalignant and malignant colorectal neoplasms
Alcohol, smoking and the risk of premalignant and malignant colorectal neoplasms
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DOI：
10.1016/j.bpg.2017.09.012
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发表时间：
2017-10-01
影响因子：
3.2
通讯作者：
Coleman, Helen G.
中科院分区：
文献类型：
--
作者：
Fagunwa, Ifewumi O.;Loughrey, Maurice B.;Coleman, Helen G.
结直肠癌（CRC）是全球第三大常见癌症，其病因复杂，由环境和遗传因素组成。在这篇综述中，我们评估了饮酒和吸烟在结直肠肿瘤中的作用。饮酒和吸烟与结直肠癌、腺瘤和锯齿状息肉的风险适度但显着增加有关。有一致的证据表明酒精和吸烟以及这些肿瘤的风险之间存在剂量反应关系。与结直肠癌的发展相比，酒精和吸烟似乎与结直肠息肉的关系更为密切，这表明酒精和吸烟在肿瘤生长的引发中发挥了作用。与增生性息肉相比，这些生活方式因素似乎与腺瘤和无蒂锯齿状病变的相关性更强，但还需要进一步证实。胃肠病学界在解决与结直肠癌和息肉相关的可改变因素方面发挥着重要但目前尚未充分利用的作用。这些行为包括但不限于饮酒和吸烟。 (C) 2017 Elsevier Ltd. 保留所有权利。
Colorectal cancer (CRC) is the third most common cancer worldwide and has a complex aetiology consisting of environmental and genetic factors. In this review, we evaluate the roles of alcohol and tobacco smoking in colorectal neoplasia. Alcohol intake and tobacco smoking are associated with modest, but significantly, increased risks of CRC, adenomatous and serrated polyps. There is consistent evidence of dose-response relationships for both alcohol and smoking, and risk of these neoplasms. Alcohol and smoking appear to be more strongly associated with colorectal polyp than CRC development, suggesting roles in the initiation of neoplastic growths. These lifestyle factors also seem more strongly related to adenomas and sessile serrated lesions than hyperplastic polyps, but further confirmation is required. The gastroenterology community has an important, yet currently underexploited, role to play addressing the modifiable factors associated with CRC and polyps. These behaviours include, but are not limited to, alcohol and smoking. (C) 2017 Elsevier Ltd. All rights reserved.