The Drosophila ramshackle gene encodes a chromatin-associated protein required for cell morphology in the developing eye
The Drosophila ramshackle gene encodes a chromatin-associated protein required for cell morphology in the developing eye
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DOI：
10.1016/j.mod.2006.06.007
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发表时间：
2006-08-01
影响因子：
2.6
通讯作者：
Moses, Kevin
中科院分区：
文献类型：
--
作者：
D'Costa, Allison;Reifegerste, Rita;Moses, Kevin
我们已经确定ranishackle(雨)是在发育中的果蝇眼睛中对刺猬功能丧失的主要抑制因素。我们已经确定了该基因的特征，它编码一个含有8个WD40重复序列的双溴结构域蛋白。Ram蛋白主要定位于多线染色体带间，是某些基因转录所必需的。Ram是一种必不可少的基因，零突变体会在幼虫的一生中死亡。在发育中的视网膜中，RAIN突变细胞具有形态缺陷，包括顶端连接中断、肌动蛋白细胞骨架紊乱和细胞核错位，伴随而来的是细胞周期转换延迟和分化标志物的表达。Ram是一个保守的基因：它的脊椎动物同源基因(WDR9)位于唐氏综合症关键区域2(DCR2)，也被认为与梵天相关基因1(BRG1)有关。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
We have identified ranishackle (rain) as a dominant suppressor of hedgehog loss-of-function in the developing Drosophila eye. We have characterized the gene and it encodes a double bromodomain protein with eight WD40 repeats. The Ram protein is localized predominantly to polytene chromosome interbands and is required for the transcription of some genes. ram is an essential gene and null mutants die during larval life. In the developing retina, rain mutant cells have morphological defects including disrupted apical junctions, disorganized actin cytoskeletons and mislocalized nuclei, which are followed by delays in cell-cycle transitions and the expression of differentiation markers. ram is a conserved gene: its vertebrate homolog (WDR9), which lies in Down's Syndrome Critical region 2 (DCR2) is also known to be associated with Brahma-Related-Gene 1 (BRG1). (c) 2006 Elsevier Ireland Ltd. All rights reserved.