Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones
Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones
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DOI：
10.1021/acs.orglett.9b02342
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发表时间：
2019-08-16
期刊：
影响因子：
5.2
通讯作者：
Garg, Neil K.
中科院分区：
文献类型：
--
作者：
Boit, Timothy B.;Mehta, Milauni M.;Garg, Neil K.
报告了在弱碱性条件下实现酮的 Meerwein-Ponndorf-Verley (MPV) 还原的实验方案。该转化可耐受一系列酮底物，包括含 O 和 S 的杂环，具有可扩展性，并显示出用作获取对映体富集产品的平台的潜力。这些研究提供了一种在温和碱性条件下实现酮还原的通用方法，并为更知名的基于 AI 的 MPV 还原条件提供了替代方案。
An experimental protocol to achieve the Meerwein-Ponndorf-Verley (MPV) reduction of ketones under mildly basic conditions is reported. The transformation is tolerant of a range of ketone substrates, including O- and S-containing heterocycles, is scalable, and shows potential to be used as a platform to access enantioenriched products. These studies provide a general method for achieving the reduction of ketones under mildly basic conditions and offer an alternative protocol to more well-known AI-based MPV reduction conditions.