Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies
Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies
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DOI：
10.1093/ndt/13.6.1438
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发表时间：
1998-06-01
影响因子：
6.1
通讯作者：
Eladari, D
中科院分区：
文献类型：
--
作者：
Montseny, JJ;Kleinknecht, D;Eladari, D
Background. The prognosis of monoclonal gammopathies with multiple myeloma and renal involvement is poor, and the indication for renal replacement therapy is controversial. Few studies address the value of renal histology for determining prognosis according to initial pathology findings.Methods. We studied the course of 118 patients with multiple myeloma according to renal biopsy lesions. The monoclonal component was identified and quantified in serum and urine. Tumor cell mass was classified as stage 1, 2 or 3, according to Durie and Salmon, End-points were death, or survival on dialysis, or serum creatinine level at last examination.Results. Renal biopsy showed myeloma kidney in 48 cases (41%), AL-amyloidosis in 35 (30%), light chain deposit disease in 22 (19%), chronic tubulointerstitial nephritis in 12 (10%) and cryoglobulinaemic kidney with multiple myeloma in 1. Maintenance haemodialysis was required in 46 patients (39%), earlier (P
