Enhanced neural activation with blueberry supplementation in mild cognitive impairment.
Enhanced neural activation with blueberry supplementation in mild cognitive impairment.
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DOI：
10.1080/1028415x.2017.1287833
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发表时间：
2018-05
影响因子：
3.6
通讯作者：
Krikorian R
中科院分区：
文献类型：
--
作者：
Boespflug EL;Eliassen JC;Dudley JA;Shidler MD;Kalt W;Summer SS;Stein AL;Stover AN;Krikorian R
临床前研究表明，蓝莓补充剂可以改善老年动物的认知能力和神经功能，并确定了花青素与这些益处之间的关联。初步的人体试验也表明老年人的认知能力有所改善，尽管尚未证明大脑功能增强的直接证据。在这项研究中，我们调查了蓝莓补充剂对老年痴呆症风险患者区域大脑激活的影响。在一项随机、双盲、安慰剂对照试验中，我们在工作记忆任务期间进行了干预前后的功能性磁共振成像，以评估蓝莓补充剂对轻度认知障碍老年人血氧水平依赖（BOLD）信号的影响，轻度认知障碍是痴呆症的风险条件。在每日补充16周后，蓝莓治疗的参与者在工作记忆负荷条件下表现出左中央前回、左额中回和左顶叶下叶的BOLD激活增加（校正p < 0.01）。没有明确的迹象表明蓝莓补充剂与工作记忆增强有关。饮食记录表明，在干预之外，花青素的摄入量没有组间差异。这些数据首次证明，在认知能力下降的蓝莓治疗老年人的工作记忆挑战期间，神经元反应增强，并且与先前的试验一致，这些试验表明蓝莓补充剂在这一高危人群中具有神经认知益处。
Preclinical studies have shown that blueberry supplementation can improve cognitive performance and neuronal function in aged animals and have identified associations between anthocyanins and such benefits. Preliminary human trials also suggest cognitive improvement in older adults, although direct evidence of enhancement of brain function has not been demonstrated. In this study, we investigated the effect of blueberry supplementation on regional brain activation in older adults at risk for dementia. In a randomized, double-blind, placebo-controlled trial we performed pre- and post-intervention functional magnetic resonance imaging during a working memory task to assess the effect of blueberry supplementation on blood oxygen level-dependent (BOLD) signal in older adults with mild cognitive impairment, a risk condition for dementia. Following daily supplementation for 16 weeks, blueberry-treated participants exhibited increased BOLD activation in the left pre-central gyrus, left middle frontal gyrus, and left inferior parietal lobe during working memory load conditions (corrected p < 0.01). There was no clear indication of working memory enhancement associated with blueberry supplementation. Diet records indicated no between-group difference in anthocyanin consumption external to the intervention. These data demonstrate, for the first time, enhanced neuronal response during working memory challenge in blueberry-treated older adults with cognitive decline and are consistent with prior trials showing neurocognitive benefit with blueberry supplementation in this at-risk population.