Iridium-catalysed condensation of alcohols and amines as a method for aminosugar synthesis
Iridium-catalysed condensation of alcohols and amines as a method for aminosugar synthesis
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DOI：
10.1039/c1cc12800k
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Martin-Matute, Belen
中科院分区：
文献类型：
--
作者：
Cumpstey, Ian;Agrawal, Santosh;Martin-Matute, Belen
在[Cp*IrCl2](2)存在下，伯碳和仲碳上的伯碳胺与醇发生烷基化反应。当初级碳水化合物醇作为偶联对时，在Cs2CO3存在下，得到了胺连接的假二糖。在这些条件下，二次碳水化合物醇不受影响，这允许区域选择性反应。
Primary carbohydrate amines at primary and secondary carbons are alkylated by alcohols in the presence of [Cp*IrCl2](2). When primary carbohydrate alcohols are used as the coupling partners and in the presence of Cs2CO3, amine-linked pseudodisaccharides are obtained. Secondary carbohydrate alcohols are unaffected under these conditions, which allows regioselective reactions.