Laboratory Tests to Assess Patients with Rheumatoid Arthritis: Advantages and Limitations
Laboratory Tests to Assess Patients with Rheumatoid Arthritis: Advantages and Limitations
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DOI：
10.1016/j.rdc.2009.10.007
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发表时间：
2009-11-01
影响因子：
2.3
通讯作者：
Sokka, Tuulikki
中科院分区：
文献类型：
--
作者：
Pincus, Theodore;Sokka, Tuulikki
实验室检查为诊断和管理许多疾病提供了最明确的信息，大多数患者将实验室检查视为医疗访问中最重要的信息。大多数类风湿关节炎（RA）患者的类风湿因子和抗环瓜氨酸肽（抗CCP）抗体检测呈阳性，红细胞沉降率（ESR）和C反应蛋白（CRP）升高。然而，超过30%-40%的RA患者的类风湿因子或抗CCP抗体检测呈阴性，ESR或CRP正常。然而，超过30%的RA患者类风湿因子或抗CCP抗体检测阴性，40%的患者ESR或CRP正常。这些观察结果表明，虽然它们可以帮助监测某些患者，但实验室测量不能作为诊断和管理所有RA或任何风湿性疾病患者的金标准。提高对实验室检查在诊断和管理类风湿关节炎患者中的局限性的认识，将使医生和患者受益。
Laboratory tests provide the most definitive information for diagnosing and managing many diseases, and most patients look to laboratory tests as the most important information from a medical visit. Most patients who have rheumatoid arthritis (RA) have a positive test for rheumatoid factor and anticyclic citrullinated peptide (anti-CCP) antibodies, as well as an elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). More than 30% 40% of patients with RA, however, have negative tests for rheumatoid factor or anti-CCP antibodies or a normal ESR or CRP. More than 30% of patients with RA, however, have negative tests for rheumatoid factor or anti-CCP antibodies, and 40% have a normal ESR or CRP. These observations indicate that, although they can be helpful to monitor certain patients, laboratory measures cannot serve as a gold standard for diagnosis and management in all individual patients with RA or any rheumatic disease. Physicians and patients would benefit from an improved understanding of the limitations of laboratory tests in diagnosis and management of patients with RA.