Time course of hepatitis E-specific antibodies in adults
Time course of hepatitis E-specific antibodies in adults
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DOI：
10.1111/jvh.12621
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发表时间：
2017-01-01
影响因子：
2.5
通讯作者：
Wenzel, J. J.
中科院分区：
文献类型：
--
作者：
Schemmerer, M.;Rauh, C.;Wenzel, J. J.
戊型肝炎病毒（HEV）在工业化国家高度流行，但缺乏对个体和整体抗体浓度动态的了解。本研究的目的是通过酶免疫测定 (EIA) 表征抗 HEV 免疫球蛋白 G（抗 HEV IgG）的纵向浓度变化。总共分析了从 18 岁以上的 45 名受试者收集的 199 份血清样本。发现了多种抗 HEV IgG 水平。总体而言，经过至少 5 年的观察期后，抗 HEV IgG 显着下降。观察到 1 例阴性血清转化。尽管预先存在 HEV 抗体，但四个个体特征表明单次甚至多次 HEV 再次感染。
Hepatitis E virus (HEV) is highly endemic in industrialized countries, but there is a lack of knowledge on individual and overall antibody concentration dynamics. The aim of this study was to characterize longitudinal concentration changes of anti-HEV immunoglobulin G (anti-HEV IgG) by enzyme immunoassay (EIA). In total, 199 serum samples collected from 45 subjects over 18years were analysed. A wide range of anti-HEV IgG levels was found. Overall, anti-HEV IgG significantly decreased after an observation period of at least 5years. One negative seroconversion was observed. Four individual profiles suggested single and even multiple HEV reinfections despite pre-existing HEV antibodies.