Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium.
Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium.
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DOI：
10.3109/08958370903161232
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发表时间：
2010-02
影响因子：
2.1
通讯作者：
Ghio AJ
中科院分区：
文献类型：
--
作者：
Cohen MD;Sisco M;Prophete C;Yoshida K;Chen LC;Zelikoff JT;Smee J;Holder AA;Stonehuerner J;Crans DC;Ghio AJ
In situ reactions of metal ions or their compounds are important mechanisms by which particles alter lung immune responses. We hypothesized that major determinants of the immunomodulatory effect of any metal include its redox behavior/properties, oxidation state, and/or solubility, and that the toxicities arising from differences in physicochemical parameters are manifest, in part, via differential shifts in lung iron (Fe) homeostasis. To test the hypotheses, immunomodulatory potentials for both penta-valent vanadium (VV; as soluble metavanadate or insoluble vanadium pentoxide) and hexavalent chromium (CrVI; as soluble sodium chromate or insoluble calcium chromate) were quantified in rats after inhalation (5 hr/d for 5 d) of each at 100 μg metal/m3. Differences in effects on local bacterial resistance between the two VV, and between each CrVI, agents suggested that solubility might be a determinant of in situ immunotoxicity. For the soluble forms, VV had a greater impact on resistance than CrVI, indicating that redox behavior/properties was likely also a determinant. The soluble VV agent was the strongest immunomodulant. Regarding Fe homeostasis, both VV agents had dramatic effects on airway Fe levels. Both also impacted local immune/airway epithelial cell Fe levels in there were significant increases in production of select cytokines/chemokines). Our findings contribute to a better understanding of the role that metal compound properties play in respiratory disease pathogenesis and provide a rationale for differing pulmonary immunotoxicities of commonly-encountered ambient metal pollutants.
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影响因子：
3
作者：
Clodfelder, BJ;Emamaullee, J;Vincent, JB
通讯作者：
Vincent, JB
影响因子：
2.2
作者：
Bella, JML;Philp, JC;Anderson, P
通讯作者：
Anderson, P
影响因子：
2.1
作者：
Cohen, MD;Sisco, M;Schlesinger, RB
通讯作者：
Schlesinger, RB
影响因子：
3.8
作者：
Cohen, MD;McManus, TP;Zelikoff, JT
通讯作者：
Zelikoff, JT
DOI：
10.1016/0020-711x(92)90258-3
发表时间：
1992-02-01
期刊：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
HARRINGTON, JP
通讯作者：
HARRINGTON, JP