Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans
Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans
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DOI：
10.1086/386292
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发表时间：
2004-05-01
影响因子：
9.8
通讯作者：
Jin, L
中科院分区：
文献类型：
--
作者：
Wen, B;Xie, XH;Jin, L
在过去的几个世纪里，由于基因从欧洲男性流向非洲和西班牙裔美国人，在美洲大陆上，亲代人口中男女血统的不平等贡献并不罕见。然而，在东亚，人们对性别偏见的混合知之甚少，在那里有大量的移民记录。藏缅族（TB）人口历史上起源于中国西北的古代部落，随后迁移到南方，在过去的2600年里，他们与南方原住民混合在一起。它们目前广泛分布在中国和东南亚。在这项研究中，我们分析了965个Y染色体和754个mtdna的变异。通过对y染色体和mtDNA标记的单倍型群体分布及其主要成分的分析，我们发现现存藏缅南部人群的遗传结构主要由两个亲本群体形成：北方移民和南方土著。此外，这种混合在男性和女性谱系之间存在偏见，在现存的stb中，北方移民对男性谱系的影响更大（类似于62%），而南方本地人对女性谱系的贡献更大（类似于56%）。这是第一个揭示STB种群性别偏向性混合的遗传证据，具有遗传、历史和人类学意义。
An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European men into African and Hispanic Americans in the past several centuries. However, little is known about sex-biased admixture in East Asia, where substantial migrations are recorded. Tibeto-Burman ( TB) populations were historically derived from ancient tribes of northwestern China and subsequently moved to the south, where they admixed with the southern natives during the past 2,600 years. They are currently extensively distributed in China and Southeast Asia. In this study, we analyze the variations of 965 Y chromosomes and 754 mtDNAs in >20 TB populations from China. By examining the haplotype group distributions of Y-chromosome and mtDNA markers and their principal components, we show that the genetic structure of the extant southern Tibeto-Burman (STB) populations were primarily formed by two parental groups: northern immigrants and native southerners. Furthermore, the admixture has a bias between male and female lineages, with a stronger influence of northern immigrants on the male lineages (similar to62%) and with the southern natives contributing more extensively to the female lineages (similar to56%) in the extant STBs. This is the first genetic evidence revealing sex-biased admixture in STB populations, which has genetic, historical, and anthropological implications.