Familial aggregation in lone atrial fibrillation
Familial aggregation in lone atrial fibrillation
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DOI：
10.1007/s00439-005-0034-8
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发表时间：
2005-11-01
期刊：
影响因子：
5.3
通讯作者：
MacRae, CA
中科院分区：
文献类型：
--
作者：
Ellinor, PT;Yoerger, DM;MacRae, CA
心房颤动（AF）是临床上最常见的心律失常，也是卒中的主要危险因素。为了研究遗传因素在典型临床人群中的作用，我们确定了孤立性房颤患者的家族聚集程度。为了估计家庭成员的相对风险，将每类亲属的房颤患病率与普通人群中可比年龄和性别组的患病率进行比较。与一般人群相比，家庭成员AF的相对风险增加（风险比; 95%置信区间）：儿子（8.1; 2.0-32）、女儿（9.5; 1.3-67）、兄弟（70; 47-102）、姐妹篇（34; 14-80）、母亲（4.0; 2.5-6.5）和父亲（2.0; 1.2-3.6）。孤立性房颤先证者的亲属发生这种心律失常的风险显著增加，这表明孟德尔遗传对这种常见特征的病因学有贡献。
Atrial fibrillation (AF) is the most common clinical arrhythmia and a major risk factor for stroke. To investigate the role of genetic factors in a typical clinical population, we determined the extent of familial aggregation in patients with lone AF. To estimate the relative risk to family members, the prevalence of AF for each class of relative was compared to the prevalence in the comparable age and sex group from the general population. Family members had an increased relative risk of AF compared to the general population (risk ratio; 95% confidence intervals): sons (8.1; 2.0-32), daughters (9.5; 1.3-67), brothers (70; 47-102), sisters (34; 14-80), mothers (4.0; 2.5-6.5) and fathers (2.0; 1.2-3.6). Relatives of probands with lone AF are at a substantially increased risk of developing this arrhythmia suggesting a Mendelian genetic contribution to the etiology of this common trait.