Sirtuins as emerging anti-parasitic targets.
Sirtuins as emerging anti-parasitic targets.
复制标题
DOI：
10.1016/j.ejmech.2012.11.014
复制
发表时间：
2013
影响因子：
6.7
通讯作者：
Weiping Zheng
中科院分区：
文献类型：
--
作者：
Weiping Zheng
Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of NAD+-dependent protein Nε-acetyl-lysine (AcK) deacetylases. Sirtuins are also evolutionarily conserved proteins that are present in all kingdoms of life ranging from bacteria to humans. Interestingly, it was recently found that the sirtuins found in various human parasites (especially the Plasmodium, Trypanosoma, and Leishmania species) were pro-survival for the parasites under various conditions. Therefore, these parasitic sirtuins have emerged as novel anti-parasitic therapeutic targets. This article reviews the currently available structural, biochemical, pharmacological, and medicinal chemistry studies on these enzymes, and discusses the perspectives of selectively targeting the parasitic sirtuins as a novel therapeutic strategy for the human parasitic diseases.
