NMR based biomarkers to study age-related changes in the human quadriceps
NMR based biomarkers to study age-related changes in the human quadriceps
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DOI：
10.1016/j.exger.2015.06.015
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发表时间：
2015-10-01
影响因子：
3.9
通讯作者：
Carlier, Pierre G.
中科院分区：
文献类型：
--
作者：
Azzabou, Noura;Hogrel, Jean-Yves;Carlier, Pierre G.
与年龄相关的石棺减少是一个主要的健康问题。为了提高老年人的生活质量，重要的是要确定骨骼肌内与年龄相关的结构变化。核磁共振成像提供了监控这些变化的定量工具。我们扫描了93名受试者：33名年龄在19岁到27岁之间的年轻人和60名年龄在69岁到80岁之间的老年人。使用三轴加速度计评估他们的体力活动，并将他们归类为活动或久坐不动。运行标准多层多回波(MSME)序列，并使用三指数拟合法提取水T2图。脂肪分数采用三点Dixon法进行定量。统计分析(ANOVA)结果显示，老年组的水T2平均值及其异质性指数和脂肪分数均显著高于老年组(p<；0.05)。与久坐组相比，运动组只有脂肪含量显著降低(p<；0.05)。线性回归证实了年龄对这些核磁共振参数的显着影响，而体力活动的影响不是系统性的。核磁共振成像提供了老化过程对骨骼肌组成的影响的全面评估。水分T2的增加可能与纤维类型的改变有关，而T2的异质性增加可能与一定程度的组织紊乱有关，如间质纤维化的发展。体力活动部分减缓了脂肪含量和水分T2异质性的增加。这些变化与性别无关。(C)2015年提交人。由爱思唯尔公司出版。这是CC BY-NC-ND许可证(http://creativecommons.org/licenses/by-nc-nd/4.0/).下的一篇开放获取文章
Age-related sarcopenia is a major health issue. To improve elderly person quality of life, it is important to characterize age-associated structural changes within the skeletal muscle. NMR imaging offers quantitative tools to monitor these changes. We scanned 93 subjects: 33 young adults aged between 19 and 27 years old and 60 older adults between 69 and 80 years old. Their physical activity was assessed using a tri-axial accelerometer and they were classified either as active or sedentary. A standard multi-slice multi-echo (MSME) sequence was run and water T2 maps were extracted using a tri-exponential fit. Fat fraction was quantified using three-point Dixon technique. Each quadriceps muscle was characterized by: water T2 mean value, water T2 heterogeneity and the mean fat fraction.Statistical analysis (ANOVA) showed that water T2 mean values and its heterogeneity indices as well as fat fraction were significantly higher in the elderly group (p < 0.05). Only fat fraction was significantly lower in the active group compared to the sedentary one (p < 0.05). Linear regression confirmed the significant impact of age on these NMR parameters whereas physical activity impact was not systematic. NMR imaging provided a comprehensive assessment of the aging process impact on skeletal muscle composition. Water T2 increase might be related to changes in fiber typology while increased T2 heterogeneities might correlate with some degree of tissue disorganization, like the development of interstitial fibrosis. Fat fraction and water T2 heterogeneity increase was partly slowed down by physical activity. These changes were not gender dependent. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).