Aerobic exercise training increases brain volume in aging humans
Aerobic exercise training increases brain volume in aging humans
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DOI：
10.1093/gerona/61.11.1166
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发表时间：
2006-11-01
影响因子：
5.1
通讯作者：
Kramer, Arthur F.
中科院分区：
文献类型：
--
作者：
Colcombe, Stanley J.;Erickson, Kirk I.;Kramer, Arthur F.
背景资料。本研究调查了老年人的有氧健身训练是否可以增加与年龄相关的脑结构和认知能力下降相关区域的脑容量。59名健康但久坐不动的社区志愿者，年龄60-79岁，参加了为期6个月的随机临床试验。一半的老年人参加有氧训练组，另一半的老年人参加调理和拉伸对照组。20名青年作为磁共振成像(MRI)的对照，没有参加运动干预。在为期6个月的健身干预之前和之后，收集了来自3D破坏梯度回忆采集MRI图像的灰质和白质体积的高空间分辨率估计。还获得了最大摄氧量(VO2)的估计值。对于参加有氧健身训练的老年人来说，大脑灰质和白质区域的体积显著增加是健身训练的结果，但参加拉伸和调理(非有氧)对照组的老年人则没有。正如预测的那样，我们的年轻参与者的灰质或白质体积都没有检测到明显的变化。这些结果表明，在老年人中，心血管健康与大脑组织的节制有关。此外，这些结果表明，有氧健身在维持和增强老年人中枢神经系统健康和认知功能方面的作用具有很强的生物学基础。
Background. The present study examined whether aerobic fitness training of older humans can increase brain volume in regions associated with age-related decline in both brain structure and cognition.Methods. Fifty-nine healthy but sedentary community-dwelling volunteers, aged 60-79 years, participated in the 6-month randomized clinical trial. Half of the older adults served in the aerobic training group, the other half of the older adults participated in the toning and stretching control group. Twenty young adults served as controls for the magnetic resonance imaging (MRI), and did not participate in the exercise intervention. High spatial resolution estimates of gray and white matter volume, derived from 3D spoiled gradient recalled acquisition MRI images, were collected before and after the 6-month fitness intervention. Estimates of maximal oxygen uptake (VO2) were also obtained.Results. Significant increases in brain volume, in both gray and white matter regions, were found as a function of fitness training for the older adults who participated in the aerobic fitness training but not for the older adults who participated in the stretching and toning (nonaerobic) control group. As predicted, no significant changes in either gray or white matter volume were detected for our younger participants.Conclusions. These results suggest that cardiovascular fitness is associated with the sparing of brain tissue in aging humans. Furthermore, these results suggest a strong biological basis for the role of aerobic fitness in maintaining and enhancing central nervous system health and cognitive functioning in older adults.