Antimalarial drug resistance in Africa: key lessons for the future.
Antimalarial drug resistance in Africa: key lessons for the future.
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DOI：
10.1111/nyas.12766
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发表时间：
2015-04
影响因子：
5.2
通讯作者：
Laufer MK
中科院分区：
文献类型：
--
作者：
Takala-Harrison S;Laufer MK
由于抗疟药物的广泛使用，抗药性寄生虫一再出现，并在很大程度上导致世界各地未能控制和根除疟疾。在这篇综述中，我们描述了传播的耐药性氯喹和磺胺嘧啶乙胺嘧啶，两个老的药物，不再使用，由于耐药率高，并检查药物压力的消除对耐药寄生虫的生存的影响。抗青蒿素疟疾目前正在东南亚以一种独特和意想不到的模式出现。我们将回顾最新的基因组和临床数据，以帮助预测对新抗疟药物的耐药性行为，并为未来预防非洲抗药性疟疾传播的战略提供信息。
Drug-resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs and have contributed significantly to the failure to control and eradicate malaria throughout the world. In this review, we describe the spread of resistance to chloroquine and sulfadoxine–pyrimethamine, two old drugs that are no longer used owing to high rates of resistance, and examine the effect of the removal of drug pressure on the survival of resistant parasites. Artemisinin-resistant malaria is now emerging in Southeast Asia in a unique and unexpected pattern. We will review the most recent genomic and clinical data to help predict the behavior of resistance to new antimalarial medications and inform strategies to prevent the spread of drug-resistant malaria in Africa in the future.