Magnetically actuated microrobots as a platform for stem cell transplantation
Magnetically actuated microrobots as a platform for stem cell transplantation
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DOI：
10.1126/scirobotics.aav4317
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发表时间：
2019-05-29
期刊：
影响因子：
25
通讯作者：
Choi, Hongsoo
中科院分区：
文献类型：
--
作者：
Jeon, Sungwoong;Kim, Sangwon;Choi, Hongsoo
磁性微型机器人专为三维培养以及体外、离体和体内干细胞的精确输送而开发。附着在微型机器人上的海马神经干细胞增殖并分化为星形胶质细胞、少突胶质细胞和神经元。此外，微型机器人被用来将结直肠癌细胞运输到芯片体内的肿瘤微组织，该芯片包含体外肝脏肿瘤微器官网络。微型机器人也在小鼠脑切片和大鼠脑血管中受到控制。最后，携带来自人类鼻子的间充质干细胞的微型机器人在裸鼠的腹腔内进行操作。结果表明微型机器人在干细胞培养和输送方面的潜力。
Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.