Pattern visual evoked cortical potentials in patients with toxic optic neuropathy caused by toluene abuse
Pattern visual evoked cortical potentials in patients with toxic optic neuropathy caused by toluene abuse
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DOI：
10.1016/s0021-5155(99)00102-1
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发表时间：
1999-09-01
影响因子：
2.4
通讯作者：
Adachi-Usami, E
中科院分区：
文献类型：
--
作者：
Kiyokawa, M;Mizota, A;Adachi-Usami, E
目的：电生理学评价甲苯滥用引起的中毒性神经病变患者的视功能。方法：15例患者（平均年龄25.6岁，8男7女）被诊断为双侧视神经病变。结果：5例患者初诊视力<0.1，10例患者视力在0.1-1.0之间。对15例PVECP进行了随访。首次记录时，11例双眼均未记录到PVECP，3例双眼P100峰潜伏期延长，1例双眼P100峰潜伏期正常。治疗后视力提高2行以上者6例，其中3例PVECPs P100峰潜伏期正常。结论：甲苯型视神经病变患者PVECP的P100峰潜伏期随着视力的提高而缩短。这些患者的VECP异常表明，长期暴露于甲苯后对视神经有严重影响。(C)1999年日本眼科学会。
Purpose: Electrophysiological evaluation of the visual function of patients with toxic neuropathy caused by toluene abuse.Methods: Fifteen patients (mean age 25.6 years, eight men and seven women) were diagnosed with bilateral optic neuropathy. Pattern visual evoked cortical potentials (PVECPs) and clinical symptoms were investigated.Results: Visual acuities at the initial visit were less than 0.1 in 5 cases and 0.1-1.0 in 10 cases. PVECPs were followed up in the 15 cases. At the first recording, PVECPs were nonrecordable in both eyes of 11 cases, the P100 peak latency was prolonged in both eyes of 3 cases, and only 1 case showed a normal P100 peak latency. After treatment, visual acuities improved more than 2 lines in 6 cases, 3 of whom showed nor mal P100 peak latency in the PVECPs. Visual prognosis and PVECP changes were identical in both eyes of all patients.Conclusions: In patients with toluene optic neuropathy, the P100 peak latency of PVECP shortened as visual acuity improved. The VECP abnormalities in these patients suggest that there is a severe effect on the optic nerve after prolonged exposure to toluene. (C) 1999 Japanese Ophthalmological Society.