Charge transport in DNA molecules: Cooperative interplay between the disordered base-pair channel and the ordered backbone.
Charge transport in DNA molecules: Cooperative interplay between the disordered base-pair channel and the ordered backbone.
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DOI：
10.1103/physreve.80.051901
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发表时间：
2009-11
期刊：
影响因子：
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通讯作者：
Wei Zhang;Rong-ge Yang;S. Ulloa
中科院分区：
文献类型：
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作者：
Wei Zhang;Rong-ge Yang;S. Ulloa
DNA分子中的电荷输运由于其在生物过程中的重要性和在纳米器件中的潜在应用而引起了人们的极大兴趣。DNA分子可以被看作是由堆叠的碱基对（AT，CG）和糖磷酸骨架组成的准一维系统。出于最近的实验观察的重要性的骨干完整性，我们调查的电荷传输通过有序的骨干和无序的基础堆栈与随机序列之间的相互作用。通过分析和数值计算，我们发现主链和碱基对通道之间的耦合在电荷输运中起着重要的作用。主链可以产生有效的跳跃常数远远超出相邻的碱基对，增强电荷通过碱基对通道的传输。定位长度的相应增强几乎与DNA的长度无关，并且随着骨架和碱基对之间的耦合的增加而增加。我们的模型可以定性地解释几个实验观察。
Charge transport in DNA molecules has raised considerable interest because of its importance in biological processes and potential applications in nanoscale devices. A DNA molecule can be viewed as a quasi-one-dimensional system composed of stacked base pairs (AT , CG) together with backbones of sugar phosphates. Motivated by recent experimental observations on the importance of the backbone integrity, we investigate the interplay between charge transport through the ordered backbone and disordered base stacks with random sequences. By analytical and numerical calculations, we find that the coupling between the backbone and base-pair channels plays an important role in charge transport. The backbone can generate effective hopping constants well beyond the adjacent base pairs, enhancing charge transport through the base-pair channel. The corresponding enhancement of the localization length is nearly independent of the length of the DNA and increases with increasing coupling between backbone and base pair. Our model can explain qualitatively several experimental observations.