Occurrence of perfluorinated substances in an adult German population in southern Bavaria
Occurrence of perfluorinated substances in an adult German population in southern Bavaria
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DOI：
10.1007/s00420-006-0136-1
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发表时间：
2007-02-01
影响因子：
3
通讯作者：
Liebl, B.
中科院分区：
文献类型：
--
作者：
Fromme, H.;Midasch, O.;Liebl, B.
目标：全氟化合物（pfc）是几十年来生产的一大组化学品，广泛用于许多工业和消费用途。由于它们在全球范围内存在于不同的环境介质中，它们的持久性以及它们在生物体中生物积累的潜力，它们引起了毒理学和公众的关注。方法：本研究对2005年在德国收集的356份成人血浆样本中全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的内暴露量进行了定量分析。结果：我们能够在所有血浆样品中检测到目标分析物，并观察到PFOS和PFOA浓度之间存在显著相关性。在女性参与者中，PFOS和PFOA的水平分别在2.5-30.7 μ g/l（中位数：10.9 μ g/l）和1.5-16.2 μ g/l（中位数：4.8 μ g/l）之间。在男性中，我们观察到全氟辛烷磺酸的浓度为2.1至55.0 μ g/l（中位数：13.7 μ g/l），全氟辛烷磺酸的浓度为0.5至19.1 μ g/l（中位数：5.7 μ g/l）。全氟辛烷磺酸和全氟辛酸浓度与性别之间存在显著相关性。我们还发现pfc水平随着参与者年龄的增加而增加，但这种关联仅在女性中具有统计学意义。结论：我们的数据与欧洲最近的其他研究结果一致，表明目前德国成年人的暴露量低于美国和加拿大人口的暴露量。人类接触的来源目前还不清楚。毒理学影响仅限于动物研究和职业调查，不足以对人类进行定量风险评估。总体而言，有必要进行更多的科学研究，以确定全氟化合物的身体负担（特别是对相关人群）以及导致人类接触这些化合物和可能对健康产生影响的主要来源和途径。
Objectives: Perfluorinated compounds (PFCs) are a large group of chemicals produced for several decades and widely used for many industrial and consumer applications. Because of their global occurrence in different environmental media, their persistence, and their potential to bioaccumulate in organisms they are of toxicological and public concern.Methods: In the present study, the internal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in 356 human plasma samples collected from an adult population in Germany in 2005 is quantified.Results: We were able to detect the target analytes in all plasma samples and observed a significant correlation between the PFOS and PFOA concentrations. In female participants, the levels of PFOS and PFOA ranged between 2.5-30.7 (median: 10.9 mu g/l) and 1.5-16.2 mu g/l (median: 4.8 mu g/l), respectively. In males we observed concentrations from 2.1 to 55.0 mu g/l (median: 13.7 mu g/l) for PFOS and from 0.5 to 19.1 mu g/l (median: 5.7 mu g/l) for PFOA. A significant correlation between both PFOS and PFOA concentrations and gender was observed. We also found increased levels of the PFCs with increasing age of the participants, but this association reached statistical significance among females only.Conclusions: Our data agree well with results of other recent studies in Europe and suggest that the current exposure of the adult German population is lower than the exposure of the US and Canadian population. The sources of human exposure are currently not well understood. Toxicological implications are restricted to animal studies and occupational investigations not adequate for quantitative risk assessment in humans. Overall, more scientific research is necessary to characterize the body burden of PFCs (especially for relevant subsets of the population) and the main sources and routes, which are responsible for human exposure and possible health implications of these compounds.