Incubation of food craving is independent of macronutrient composition.
Incubation of food craving is independent of macronutrient composition.
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DOI：
10.1038/srep30900
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发表时间：
2016-08-03
影响因子：
4.6
通讯作者：
Brown TE
中科院分区：
文献类型：
--
作者：
Darling RA;Dingess PM;Schlidt KC;Smith EM;Brown TE
先前与奖励刺激配对的线索诱导动机渴望状态的时间依赖性增加（渴望的孵化）。随着时间的推移，对高脂肪（HF）食物的渴望是否会增加，这可能会导致暴饮暴食和肥胖，尚未确定。我们假设与HF颗粒配对的线索会比与标准食物（SC）颗粒配对的线索引起更大的渴望效应的孵化。暴露于HF或SC颗粒相关线索的大鼠在30天的禁欲期内表现出同等水平的渴望。SC颗粒和LabDiet之间的饮食偏好测试显示，SC颗粒优于LabDiet。大鼠饲养的SC颗粒完全，没有表现出孵化的渴望SC颗粒，这表明先前的历史与食物线索诱导的寻求行为中起着重要的作用。结果发现，以前与食物相关的线索经历了一个相当大的孵化渴望。当禁食30天后测量摄食行为时，大鼠显著增加了HF颗粒的消耗量。我们的研究结果表明，随着时间的推移，食物线索获得的重要性，触发增加的方法行为，并增加消费的HF食品后禁欲。这可能会导致暴饮暴食和肥胖的发展。
Cues previously paired with rewarding stimuli induce a time-dependent increase in the motivational craving state (incubation of craving). Whether there is an increase in craving for high-fat (HF) food over time, which may contribute to overeating and obesity, has not been determined. We hypothesized that cues paired with HF pellets would elicit a greater incubation of craving effect than those paired with standard chow (SC) pellets. Rats exposed to cues associated with either HF or SC pellets demonstrated equivalent levels of craving over an abstinence period of 30 days. Diet preference tests between SC pellets and LabDiet revealed that SC pellets were preferred over LabDiet. Rats reared on SC pellets exclusively, did not display incubation of craving for SC pellets, suggesting that prior history with the food plays an important role in cue-induced seeking behavior. Results identified cues previously associated with food undergo a comparable magnitude of incubation of craving. When ingestive behavior was measured after 30 days of abstinence, rats significantly increased their consumption of HF pellets. Our results indicate that food cues gain importance over time, trigger increased approach behaviors, and increased consumption of HF food following abstinence. This may contribute to overeating and the development of obesity.