Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications
Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications
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DOI：
10.1016/j.actbio.2009.09.018
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发表时间：
2010-03-01
影响因子：
9.7
通讯作者：
de Queiroz, A. A. A.
中科院分区：
文献类型：
--
作者：
Torres Vargas, E. A.;do Vale Baracho, N. C.;de Queiroz, A. A. A.
这项研究报告的性能，能够提供一个活性剂递送伤口敷料应用的电纺超支化聚甘油纳米纤维。这项工作的目的是制备含有金盏花作为伤口愈合和抗炎剂的电纺HPGL纳米纤维。用扫描电镜对静电纺HPGL-C officinalis纳米纤维的形貌进行了分析，结果表明，纤维的直径为纳米级。在生理温度下，用高效液相色谱法测定了不同浓度的药用植物C（37 ℃）由于电纺HPGL-C officinalis膜的高溶胀能力以及高孔隙率，显示出C officinalis从电纺HPGL-C officinalis纳米纤维中的快速释放。溶胀度，结果表明，在生理条件下，HPGL纤维的吸水率随纤维长度的增加而增加，但随着纤维长度的增加，吸水率增加。电纺纤维减慢，这取决于电纺HPGL-C officinalis膜与生理流体相互作用的速率。C officinalis的释放速率似乎取决于HPGL纳米纤维中的C officinalis含量。从弹性模量可以看出，随着HPGL-C officinalis膜中C含量的增加，可以获得弹性静电纺丝HPGL纤维。大鼠体内实验的结果表明，HPGL-C officinalis可能是一种有趣的生物活性伤口敷料材料，可用于临床应用（C）2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved。
This study reports on the performance of electrospun hyperbranched polyglycerol nanofibers capable of providing an active agent delivery for wound dressing applications The aim of this work was to prepare electrospun HPGL nanofibers containing Calendula officinalis as a wound-healing and anti-inflammatory agent. The morphology of the electrospun HPGL-C officinalis nanofibers was analyzed using a scanning electron microscope The results showed that the diameters of the fibers were in nanoscales. The release of C officinalis from the electrospun HPGL fibers was determined by HPLC at a physiological temperature (37 degrees C) Rapid release of the C officinalis from the electrospun HPGL-C officinalis nanofibers was exhibited as result of the high swelling ability as well as the high porosity of the electrospun HPGL-C officinalis membranes The degree of swelling, and the mechanical and biocompatible properties of the electrospun HPGL Fibers were determined The results showed that, in physiological conditions, the water absorption into the HPGL. electrospun fibers slowed down, governed by the rate at which the electrospun HPGL-C officinalis membranes interacted with the physiological fluid The rate of release of C officinalis seemed to depend oil the C officinalis content in the HPGL nanofibers. From the elastic modulus, It Could be seen that elastic electrospun HPGL fibers were obtained with increments of C officinalis content in the HPGL-C officinalis membranes The results of in vivo experiments in rats Suggested that HPGL-C officinalis might be an interesting bioactive wound dressing material for clinical applications (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved.