Germline mutation of microRNA-125a is associated with breast cancer
Germline mutation of microRNA-125a is associated with breast cancer
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DOI：
10.1136/jmg.2008.063123
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发表时间：
2009-05-01
影响因子：
4
通讯作者：
Jin, P.
中科院分区：
文献类型：
--
作者：
Li, W.;Duan, R.;Jin, P.
微小RNA（miRNAs）是一类小的非编码RNA，它们在转录后水平抑制特定靶基因的表达。在人类癌症中常常发现miRNAs的调控异常，它们既可以作为强效的癌基因，也可以作为肿瘤抑制基因发挥作用。在此我们表明，成熟的miR - 125a中的种系突变与乳腺癌的发生高度相关，这表明miR - 125a在人类癌症中很可能作为肿瘤抑制基因发挥作用。
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer.