Reprogramming aging and progeria
Reprogramming aging and progeria
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DOI：
10.1016/j.ceb.2012.08.009
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发表时间：
2012-12-01
影响因子：
7.5
通讯作者：
Lopez-Otin, Carlos
中科院分区：
文献类型：
--
作者：
Freije, Jose M. P.;Lopez-Otin, Carlos
生物体的衰老速度取决于组织退化与组织修复的比率。因此，使这种平衡向退化方向倾斜的分子改变会导致加速老化。相反，可以进行干预以减少组织变性或增加组织修复，目的是延迟年龄相关表现的发作。最近对衰老中干细胞生物学的研究揭示了系统因素对其功能的影响，并证明了对衰老和早衰细胞进行重编程的可行性。这些结果说明了衰老过程某些方面的可逆性，并鼓励寻找新的抗衰老和抗早衰干预措施。
The aging rate of an organism depends on the ratio of tissue degeneration to tissue repair. As a consequence, molecular alterations that tip this balance toward degeneration cause accelerated aging. Conversely, interventions can be pursued to reduce tissue degeneration or to increase tissue repair with the aim of delaying the onset of age-associated manifestations. Recent studies on the biology of stem cells in aging have revealed the influence of systemic factors on their functionality, and demonstrated the feasibility of reprogramming aged and progeroid cells. These results illustrate the reversibility of some aspects of the aging process and encourage the search for new anti-aging and anti-progeria interventions.