Macrophage dysfunction in the pathogenesis and treatment of asthma
Macrophage dysfunction in the pathogenesis and treatment of asthma
复制标题
巨噬细胞功能障碍在哮喘发病机制和治疗中的作用
DOI：
10.1183/13993003.00196-2017
复制
发表时间：
2017-09-01
影响因子：
24.3
通讯作者：
Gibson, Peter G.
中科院分区：
文献类型：
--
作者：
Fricker, Michael;Gibson, Peter G.
哮喘是一种慢性呼吸系统疾病，通常与异常气道和全身炎症有关。哮喘气道中的各种炎症表型已被描述为与临床表型和对传统和新型哮喘治疗反应的影响有关。巨噬细胞是肺中丰富的免疫细胞，能够进行体内平衡和防御病原体所需的各种反应。在这里，我们总结了哮喘中巨噬细胞功能障碍的临床证据。我们还描述了支持巨噬细胞作为哮喘治疗靶点的作用的证据。我们得出结论，哮喘中的巨噬细胞功能障碍是高度普遍和异质性的，并假设巨噬细胞可能在促进哮喘的离散炎症表型中发挥作用。这些临床发现，以及最近对肺巨噬细胞的个体发生、行为复杂性和寿命的突破性见解，支持了巨噬细胞作为哮喘疾病调节剂、生物标志物和治疗靶点的作用的持续研究。
Asthma is a chronic respiratory condition frequently associated with aberrant airway and systemic inflammation. Various inflammatory phenotypes in asthmatic airways have been described that relate to clinical phenotypes and impact on responses to conventional and novel asthma therapies. Macrophages are abundant immunocytes in the lung, capable of mounting diverse responses required for homeostasis and defence against pathogens.Here, we summarise the clinical evidence regarding macrophage dysfunction in asthma. We also describe evidence supporting the role of macrophages as therapeutic targets in asthma. We conclude that macrophage dysfunction in asthma is highly prevalent and heterogeneous, and hypothesise that macrophages may play roles in promoting the discrete inflammatory phenotypes of asthma.These clinical findings, along with recent ground-breaking insights into the ontogeny, behavioural complexity and longevity of pulmonary macrophages, support continued research into the role of macrophages as disease modifiers, biomarkers and therapeutic targets in asthma.