Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo.
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo.
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细胞衰老之外的细胞衰老：体外和体内细胞周期停滞之前的衰老标志物。
DOI：
10.1111/acel.13338
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发表时间：
2021-04
期刊：
影响因子：
7.8
通讯作者：
Ogrodnik M
中科院分区：
文献类型：
--
作者：
Ogrodnik M
细胞衰老的研究领域经历了从主要集中在体外衰老方面到动物和临床研究的广泛领域的快速扩展。细胞衰老由一组标志物定义，其中许多标志物在衰老诱导之前以逐渐的方式存在和积累，或者在细胞衰老的背景之外发现。这些标记物现在用于测量细胞衰老对衰老和疾病的影响以及抗衰老干预措施的结果，其中许多处于临床试验阶段。因此，讨论它们的特异性以及它们在衰老建立中的作用是至关重要的。在这里，衰老标志物的存在和作用在细胞周期停滞之前的细胞中进行了描述，特别是在复制老化和体内条件下。具体而言，这篇综述文章旨在描述“细胞衰老”的过程：在原代细胞中发生的内部变化的进展导致细胞衰老的诱导和细胞死亡的高潮。衰老诱导前与衰老相关的表型变化将被表征，以及它们对细胞衰老诱导和细胞最终命运的影响。使用已发表的体内衰老标志物评估数据集，将描述如何通过细胞衰老的概念解释量化之间的差异。最后，本文将讨论拓宽细胞衰老研究范式的应用价值。在衰老动物的组织中发现的细胞处于细胞衰老的不同阶段，因此在细胞周期停滞建立之前显示出与细胞衰老相关的标志物。此外，随着细胞老化的进展，体内衰老细胞可能显示出不同水平的衰老标志物，即使在衰老诱导后，细胞也会随着时间的推移而继续变化，直到死亡。
The field of research on cellular senescence experienced a rapid expansion from being primarily focused on in vitro aspects of aging to the vast territories of animal and clinical research. Cellular senescence is defined by a set of markers, many of which are present and accumulate in a gradual manner prior to senescence induction or are found outside of the context of cellular senescence. These markers are now used to measure the impact of cellular senescence on aging and disease as well as outcomes of anti‐senescence interventions, many of which are at the stage of clinical trials. It is thus of primary importance to discuss their specificity as well as their role in the establishment of senescence. Here, the presence and role of senescence markers are described in cells prior to cell cycle arrest, especially in the context of replicative aging and in vivo conditions. Specifically, this review article seeks to describe the process of “cellular aging”: the progression of internal changes occurring in primary cells leading to the induction of cellular senescence and culminating in cell death. Phenotypic changes associated with aging prior to senescence induction will be characterized, as well as their effect on the induction of cell senescence and the final fate of cells reviewed. Using published datasets on assessments of senescence markers in vivo, it will be described how disparities between quantifications can be explained by the concept of cellular aging. Finally, throughout the article the applicational value of broadening cellular senescence paradigm will be discussed. Cells found in tissues of aging animals are at different stages of cellular aging, thus showing markers associated with cellular senescence before the establishment of the cell cycle arrest. In addition, senescent cells in vivo might show different levels of senescence markers as cellular aging progresses even after senescence induction and cells continue changing over time until death.
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DOI：
10.1083/jcb.201610113
发表时间：
2017-07-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Carroll B;Nelson G;Rabanal-Ruiz Y;Kucheryavenko O;Dunhill-Turner NA;Chesterman CC;Zahari Q;Zhang T;Conduit SE;Mitchell CA;Maddocks ODK;Lovat P;von Zglinicki T;Korolchuk VI
通讯作者：
Korolchuk VI
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
11.2
作者：
Bavik, C;Coleman, I;Nelson, PS
通讯作者：
Nelson, PS
影响因子：
7.8
作者：
Busuttil, RA;Rubio, M;Vijg, J
通讯作者：
Vijg, J
影响因子：
4
作者：
Ahmed, Shaheda;Passos, Joao F.;Saretzki, Gabriele
通讯作者：
Saretzki, Gabriele