Indocyanine Green Accurately Track the Phototherapy Based on W18O49@ PLGA Nanostructure In Vivo for Visual Treat
Indocyanine Green Accurately Track the Phototherapy Based on W18O49@ PLGA Nanostructure In Vivo for Visual Treat
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吲哚菁绿基于W18O49@PLGA纳米结构准确追踪光疗体内视觉治疗
DOI：
10.1166/sam.2019.3609
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发表时间：
2019
影响因子：
0.9
通讯作者：
Wang Jin Hai
中科院分区：
文献类型：
--
作者：
Wang Hui Quan;Xia Fang;Han Jia Wen;Hu Peng Fei;Zhao Zhe;Zheng Bin;Wang Han Jie;Zheng Yu;Wang Jin Hai
随着技术的进步和发展，与传统的化疗等手术方法相比，光热治疗因其无创、副作用小等优点，在许多疾病的治疗中得到了更多的重视和尝试。氧化钨（W18 O 49，WO）是一种过度粘附的氧化物纳米颗粒，是高质量PTT效果的有吸引力的选择。聚（D，L-乳酸-羟基乙酸）具有良好的生物相容性和生物降解性，是广泛应用于药物排放的支撑组件。然而，常用的水热法难以限制WO的形貌。本文初步设计并制备了吲哚菁绿色和WO共染PLGA（（WO+ICG）@PLGA）。（WO+ICG）@PLGA纳米粒子可有效改善ICG成像过程中的光热质量，引导PTT。体内实验结果表明，纳米粒子在体内对B16肿瘤细胞具有良好的成像和光热治疗效果。该研究表明，（WO+ICG）@PLGA纳米颗粒是用于炎症相关疾病的诊断和光热治疗的极好平台。
With the progress and development of technology, compared with traditional chemotherapy and other surgical methods, photothermal therapy has been paid more attention and attempted in the treatment of many diseases due to its non-invasive and minimal secondary effect. Tungsten oxide (W18O49, WO), an overly coherent oxide nanoparticle, is an attractive option for high-quality PTT effects. Poly(D,L-lactic-co-glycolic acid) has good biocompatibility and biodegradability, and is a supporting component widely used in pharmaceutical emissions. However, the commonly used hydrothermal method is difficult to limit the morphology of WO. In this paper, Indocyanine green and WO coloaded PLGA ((WO+ICG)@PLGA) were preliminarily designed and prepared. The photothermal mass during ICG imaging can be effectively improved by (WO+ICG)@PLGA nanoparticles, to guide PTT. The results of in vivo experiments showed that nanoparticles had good effects on imaging and photothermal therapy for B16 tumor cells in vivo. The study indicated that (WO+ICG)@PLGA nanoparticles are an excellent platform for the diagnosis and photothermal therapy of inflammation-related diseases.