Prefrontal functioning during context processing in schizophrenia and major depression: An event-related fMRI study
Prefrontal functioning during context processing in schizophrenia and major depression: An event-related fMRI study
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DOI：
10.1016/j.schres.2005.01.021
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发表时间：
2005-07-15
影响因子：
4.5
通讯作者：
Cohen, JD
中科院分区：
文献类型：
--
作者：
Holmes, AJ;MacDonald, A;Cohen, JD
精神分裂症患者经常在需要执行处理的任务中表现出前额叶功能减退;然而，问题仍然存在，是否前额叶皮质功能障碍是精神分裂症特有的，还是主要精神病理学的一般特征。上下文处理被概念化为与注意和工作记忆过程相关的执行功能。精神分裂症患者表征和维持背景信息的能力受损，此前已有多项研究报道。为了研究精神分裂症的上下文处理缺陷的特异性问题，我们使用了功能性MRI和期望AX连续性能任务，旨在评估一组健康对照组（n=9），抑郁症患者对照组（n=10）和精神分裂症患者（n=7）的上下文处理。精神分裂症患者的行为表现与上下文处理缺陷一致，但与抑郁症患者不一致。成像数据重复了先前的结果，显示精神分裂症患者右额中回（BA 9）与上下文处理相关的异常活动。(c)2005年由Elsevier B. V.出版
Patients with schizophrenia frequently demonstrate hypofrontality in tasks that require executive processing; however questions still remain as to whether prefrontal cortex dysfunctions are specific to schizophrenia, or a general feature of major psychopathology. Context processing is conceptualized as an executive function associated with attention and working memory processes. Impairment in the ability of patients with schizophrenia to represent and maintain context information has been previously reported in a number of studies. To examine the question of the specificity of a context processing deficit to schizophrenia, we used functional MRI and an expectancy AX continuous performance task designed to assess context processing in a group of healthy controls (n=9), depressed patient controls (n=10), and patients with schizophrenia (n=7). The behavioral performance was consistent with a context processing deficit in patients with schizophrenia, but not those with depression. The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing. (c) 2005 Published by Elsevier B.V.