Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue.
Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue.
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DOI：
10.1007/s11914-003-0003-x
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发表时间：
2003-06-01
影响因子：
4.3
通讯作者：
Rubin, Clinton
中科院分区：
文献类型：
--
作者：
Judex, Stefan;Boyd, Steve;Rubin, Clinton
骨质疏松症患者的非创伤性骨骼骨折与骨强度的恶化直接相关。然而，骨组织无法承受功能性承重不能简单地解释为骨矿物质密度（数量）的降低;强度也明显取决于骨质量。虽然骨质量的正式定义有点难以捉摸，但至少它包含了对骨强度至关重要的结构，物理和生物因素。这些因素包括骨形态（即，骨小梁连接性、横截面几何形状、纵向曲率）;组织的材料特性（例如，刚度、强度）;其化学成分和结构（例如，钙与有机和/或无机相其他组分的比例、胶原蛋白取向、孔隙率、渗透性）;以及组织的活力（例如，骨细胞群的反应性）。结合骨的高分辨率结构指数，如通过微计算机断层扫描确定;材料特性确定的纳米压痕;和骨的化学组成，如通过红外光谱法确定，有助于提供关键信息，以更全面地评估骨质量，数量和骨折风险的相互依赖性。
Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon bone quality. While a formal definition of bone quality is somewhat elusive, at the very least, it incorporates architectural, physical, and biologic factors that are critical to bone strength. Such factors include bone morphology (ie, trabecular connectivity, cross-sectional geometry, longitudinal curvature); the tissue's material properties (eg, stiffness, strength); its chemical composition and architecture (eg, ratio of calcium to other components of the organic and/or inorganic phase, collagen orientation, porosity, permeability); and the viability of the tissue (eg, responsivity of the bone cell population). Combining high-resolution structural indices of bone, as determined by micro-computed tomography; material properties determined by nanoindentation; and the chemical make-up of bone, as determined by infrared spectroscopy, helps to provide critical information toward a more comprehensive assessment of the interdependence of bone quality, quantity, and fracture risk.