Anxiolytic-like effect of oxytocin in the simulated public speaking test
Anxiolytic-like effect of oxytocin in the simulated public speaking test
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DOI：
10.1177/0269881111400642
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发表时间：
2012-04-01
影响因子：
4.1
通讯作者：
Crippa, Jose A. S.
中科院分区：
文献类型：
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作者：
de Oliveira, Danielle C. G.;Zuardi, Antonio W.;Crippa, Jose A. S.
催产素(OT)被认为与焦虑、心血管和激素调节有关。本研究的目的是评估鼻腔给药OT对进行模拟公共演讲测试的健康志愿者(n=14)的主观状态以及心血管和内分泌参数的急性影响。试验前50分钟鼻内注射OT或安慰剂。在实验过程中进行了不同时间的评估：(1)基线(-30分钟)；(2)测试前(-15分钟)；(3)对演讲的预期(50分钟)；(4)演讲期间(1：03小时)，测试后时间1(1：26小时)，测试后时间2(1：46小时)。主观状态采用自评量表进行评定。测定血清皮质醇和血浆促肾上腺皮质激素(ACTH)水平。此外，还测量了心率、血压、皮肤电导和皮肤电导的自发波动次数。与安慰剂相比，OT仅在测试前阶段降低了视觉模拟心境量表(VAMS)的焦虑指数，而在测试前、预期和演讲阶段增加了镇静。OT还降低了测试前、预期、言语和测试后2个阶段的皮肤电导水平。被评估的其他参数不受OT的显著影响。目前的结果表明，OT减少了预期焦虑，但不影响公开演讲的恐惧，这表明这种激素具有缓解焦虑的特性。
Oxytocin (OT) is known to be involved in anxiety, as well as cardiovascular and hormonal regulation. The objective of this study was to assess the acute effect of intranasally administered OT on subjective states, as well as cardiovascular and endocrine parameters, in healthy volunteers (n = 14) performing a simulated public speaking test. OT or placebo was administered intranasally 50 min before the test. Assessments were made across time during the experimental session: (1) baseline (-30 min); (2) pre-test (-15 min); (3) anticipation of the speech (50 min); (4) during the speech (1:03 h), post-test time 1 (1:26 h), and post-test time 2 (1:46 h). Subjective states were evaluated by self-assessment scales. Cortisol serum and plasma adrenocorticotropic hormone (ACTH) were measured. Additionally, heart rate, blood pressure, skin conductance, and the number of spontaneous fluctuations in skin conductance were measured. Compared with placebo, OT reduced the Visual Analogue Mood Scale (VAMS) anxiety index during the pre-test phase only, while increasing sedation at the pre-test, anticipation, and speech phases. OT also lowered the skin conductance level at the pre-test, anticipation, speech, and post-test 2 phases. Other parameters evaluated were not significantly affected by OT. The present results show that OT reduces anticipatory anxiety, but does not affect public speaking fear, suggesting that this hormone has anxiolytic properties.