Blood levels of perfluoroalkyl substances (PFASs), elements and their associations with metabolic syndrome (MetS) in Chinese male adults mediated by metabolic-related risk factors
Blood levels of perfluoroalkyl substances (PFASs), elements and their associations with metabolic syndrome (MetS) in Chinese male adults mediated by metabolic-related risk factors
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中国男性成人中全氟烷基物质（PFAS）、元素的血液水平及其与代谢相关危险因素介导的代谢综合征（MetS）的关系
DOI：
10.1016/j.scitotenv.2020.140595
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发表时间：
2020
影响因子：
9.8
通讯作者：
Ai Gao
中科院分区：
文献类型：
--
作者：
Qiaoyun Yang;Xiaoli Guo;Yujiao Chen;Wei Zhang;Jing Ren;Jingyu Wang;Naijun Tang;Ai Gao
我们的初步研究表明，全氟磺酸、重金属和微量元素可能会对MetS造成重大风险。然而，表观遗传机制（即miRNAs）和代谢改变的危险因素（即甲状腺功能、葡萄糖和脂质代谢）的作用尚不完全清楚。为了验证这一假设，我们对80例男性met病例和64例男性文献进行了进一步的横断面研究。血清全氟辛酸（n-PFOA）与miR-140-5p呈负相关[β =−0.772；95%置信区间（CI），−0.244 ~−0.300；P < 0.01,q< 0.05)]。MetS组瘦素和总胆汁酸水平较高。瘦素与Cd （β = 1.015,p< 0.01,q< 0.05）、Cu （β = 6.796,p< 0.05,q= 0.077）、Se （β = 7.633,p< 0.05,q= 0.060）呈极显著正相关；总胆汁酸与硒含量显著相关（β = 8.954,p< 0.05,q= 0.140）。瘦素与收缩压/舒张压之间存在显著正相关。此外，总胆汁酸浓度升高与高甘油三酯血症相关[比值比（OR）： 2.24 (95%CI, 1.10-4.58)]。
Our preliminary studies have suggested PFASs, heavy metals, and trace elements could bring significant risks to MetS. However, the role of epigenetic mechanisms (i.e., miRNAs) and risk factors of metabolic alternation (i.e., thyroid functions, glucose and lipids metabolism) are not fully understood. To test this hypothesis, a further cross-sectional study with 80 male MetS cases and 64 male references was undertaken. Negative association between the serumn-perfluorooctanoic acid (n-PFOA) with miR-140-5p was found [β = −0.772; 95% confidence interval (CI), −0.244 to −0.300;p< 0.01,q< 0.05)] after adjusted with age. Higher levels of leptin and total bile acid were observed in the MetS group. The significantly positive associations between leptin with Cd (β = 1.015,p< 0.01,q< 0.05), Cu (β = 6.796,p< 0.05,q= 0.077) and Se (β = 7.633,p< 0.05,q= 0.060) were found; whereas total bile acid was significantly associated with Se (β = 8.954,p< 0.05,q= 0.140). Significantly positive associations between leptin and systolic/diastolic blood pressure were showed. Moreover, increased total bile acid concentrations were associated with hypertriglyceridemia [odds ratio (OR): 2.24 (95%CI, 1.10–4.58) adjusted by age.