Molecular Theory of Hydrophobic Effects
Molecular Theory of Hydrophobic Effects
复制标题
疏水效应的分子理论
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
A. Garcia
中科院分区：
文献类型：
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作者：
L. Pratt;G. Hummer;A. Garcia
疏水性和亲水性是水溶液中溶剂化效应的类别。典型的离子如Na或极性分子如NH3是亲水性溶质.相反，疏水溶质或基团与水分子的相互作用不显示经典的静电或特定的化学相互作用。原始疏水溶质是惰性气体和微溶于水的简单烃。然而，蛋白质的分子结构、功能和聚集激发了疏水效应的研究，因为人们普遍认为疏水相互作用驱动蛋白质折叠。这个难题的一个重要方面是，它现在似乎共同的蛋白质展开后，适当的过冷的水系统。
Hydrophobic and hydrophilic are categories of solvation effects in aqueous solutions. Classical ions such as Na or polar molecules such as NH 3 are hydrophilic solutes. In contrast, the interactions of hydrophobic solutes or groups with water molecules do not display classic electrostatic or specific chemical interactions. Primitive hydrophobic solutes are inert gases and simple hydrocarbons that are sparingly soluble in water. However, protein molecular structure, function, and aggregation motivate study of hydrophobic effects because of the widely-held view that hydrophobic interactions drive protein folding. An important aspect of this puzzle is that it now appears common for proteins to unfold upon appropriate supercooling of the aqueous system.