Imaging in the Age of Precision Medicine: Summary of the Proceedings of the 10th Biannual Symposium of the International Society for Strategic Studies in Radiology
Imaging in the Age of Precision Medicine: Summary of the Proceedings of the 10th Biannual Symposium of the International Society for Strategic Studies in Radiology
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DOI：
10.1148/radiol.2015150709
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发表时间：
2016-04-01
期刊：
影响因子：
19.7
通讯作者：
Hricak, Hedvig
中科院分区：
文献类型：
--
作者：
Herold, Christian J.;Lewin, Jonathan S.;Hricak, Hedvig
在过去的十年中，随着系统生物学的突破，精准医学（PM）已经成为一种新的医疗保健模式。PM是一种考虑到基因、环境和生活方式的个体差异的疾病治疗和预防方法，它支持医学中的还原论和基础广泛的方法。它涉及以整体方式整合来自多个来源的信息，以实现明确的诊断，重点治疗和充分的反应评估。生物医学成像和成像引导的干预，提供多参数形态和功能信息，并实现集中，微创治疗，是PM所需的基础设施的关键要素。放射基因组学的新兴学科，它将基因型信息与成像时的表型疾病表现联系起来，也应该大大有助于为患者量身定制的护理。由于成像数据的数量和复杂性不断增加，因此需要决策支持算法来帮助医生应用最重要的患者数据进行最佳管理。这些创新将挑战传统的医疗保健概念和商业模式。必须重新考虑和调整偿还政策和质量保证措施。在2013年8月举行的第10届半年度研讨会上，国际放射学战略研究学会的成员讨论了向PM过渡给成像界带来的机遇和挑战。本文综述了研讨会的讨论情况和中心思想。(C)RSNA，2015年
During the past decade, with its breakthroughs in systems biology, precision medicine (PM) has emerged as a novel health-care paradigm. Challenging reductionism and broad-based approaches in medicine, PM is an approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. It involves integrating information from multiple sources in a holistic manner to achieve a definitive diagnosis, focused treatment, and adequate response assessment. Biomedical imaging and imaging-guided interventions, which provide multiparametric morphologic and functional information and enable focused, minimally invasive treatments, are key elements in the infrastructure needed for PM. The emerging discipline of radiogenomics, which links genotypic information to phenotypic disease manifestations at imaging, should also greatly contribute to patient-tailored care. Because of the growing volume and complexity of imaging data, decision-support algorithms will be required to help physicians apply the most essential patient data for optimal management. These innovations will challenge traditional concepts of health care and business models. Reimbursement policies and quality assurance measures will have to be reconsidered and adapted. In their 10th biannual symposium, which was held in August 2013, the members of the International Society for Strategic Studies in Radiology discussed the opportunities and challenges arising for the imaging community with the transition to PM. This article summarizes the discussions and central messages of the symposium. (C) RSNA, 2015