All Proteins Have a Basic Molecular Formula
All Proteins Have a Basic Molecular Formula
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所有蛋白质都有基本分子式
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
H. Torabizadeh
中科院分区：
文献类型：
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作者：
H. Torabizadeh
这项研究提出了所有蛋白质的基本分子式。随机选择了总共 10,739 个蛋白质，属于根据其功能分类的 9 个不同蛋白质组。它们包括酶、储存蛋白、激素、信号蛋白、结构蛋白、转运蛋白、免疫球蛋白或抗体、运动蛋白和受体蛋白。使用 ProtParam 工具获得蛋白质分子式后，确定每个随机选择的样品的 H/C、N/C、O/C 和 S/C 比率。在这种情况下，H、N、O 和 S 系数是按每个碳原子指定的。令人惊讶的是，结果表明所有 10,739 种蛋白质的 H、N、O 和 S 系数相似且高度相关。这项研究表明，尽管结构和功能存在差异，但所有已知蛋白质都具有相似的基本分子式 CnH1.58 ± 0.015nN0.28 ± 0.005nO0.30 ± 0.007nS0.01 ± 0.002n。所有系数之间的总相关性为 0.9999。关键词—蛋白质分子式、基本单元公式、Protparam 工具。
This study proposes a basic molecular formula for all proteins. A total of 10,739 proteins belonging to 9 different protein groups classified on the basis of their functions were selected randomly. They included enzymes, storage proteins, hormones, signalling proteins, structural proteins, transport proteins, immunoglobulins or antibodies, motor proteins and receptor proteins. After obtaining the protein molecular formula using the ProtParam tool, the H/C, N/C, O/C, and S/C ratios were determined for each randomly selected sample. In this case, H, N, O, and S coefficients were specified per carbon atom. Surprisingly, the results demonstrated that H, N, O, and S coefficients for all 10,739 proteins are similar and highly correlated. This study demonstrates that despite differences in the structure and function, all known proteins have a similar basic molecular formula CnH1.58 ± 0.015nN0.28 ± 0.005nO0.30 ± 0.007nS0.01 ± 0.002n. The total correlation between all coefficients was found to be 0.9999. Keywords—Protein molecular formula, Basic unit formula, Protparam tool.