Arginine supplementation prevents necrotizing enterocolitis in the premature infant
Arginine supplementation prevents necrotizing enterocolitis in the premature infant
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DOI：
10.1067/mpd.2002.123289
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发表时间：
2002-04-01
影响因子：
5.1
通讯作者：
Scott, RB
中科院分区：
文献类型：
--
作者：
Amin, HJ;Zamora, SA;Scott, RB
目的：确定补充 L-精氨酸是否可以降低出生体重小于或等于 1250 g、胎龄小于或等于 32 周的早产儿各阶段坏死性小肠结肠炎 (NEC) 的发病率。 研究设计：在一项随机、双盲、安慰剂对照研究中，152 名早产儿被前瞻性地随机分配接受补充 L-精氨酸（1.5每天 mmol/1-g；n = 75 [A 组]）或安慰剂（对照组；n = 77 [B 组]），在出生后的前 28 天进行口服喂养/肠外营养。在第 3、14 和 28 天以及诊断 NEC 时测量所有婴儿的营养摄入量、血浆氨、精氨酸和氨基酸浓度。 结果：A 组有 5 名婴儿出现 NEC，而 B 组有 21 名婴儿出现 NEC（P
Objectives: To deter-mine whether supplementation with L-arginine reduces the incidence of all stages of necrotizing enterocolitis (NEC) in premature infants with birth weight less than or equal to 1250 g and gestational age less than or equal to32 weeks.Study design: In a randomized, double-blind, placebo-controlled study, 152 premature infants were prospectively, randomly assigned to receive either supplemental L-arginine (1.5 mmol/1-g per day; n =75 [group A]) or placebo (control group; n = 77 [group B]) with oral feeds/parenteral nutrition during the first 28 days of life. Nutrient intake, plasma ammonia, arginine, and amino acid concentrations were measured in all infants at days 3, 14, and 28 and at the time of diagnosis of NEC.Results: NEC developed in 5 infants in group A compared with 21 infants in group B (P