Decline in temperature and humidity increases the occurrence of influenza in cold climate.
Decline in temperature and humidity increases the occurrence of influenza in cold climate.
复制标题
温度和湿度的降低会增加寒冷气候中流感的发生。
DOI：
10.1186/1476-069x-13-22
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发表时间：
2014-03-28
期刊：
影响因子：
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通讯作者：
KIAS-Study Group
中科院分区：
文献类型：
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作者：
Jaakkola K;Saukkoriipi A;Jokelainen J;Juvonen R;Kauppila J;Vainio O;Ziegler T;Rönkkö E;Jaakkola JJ;Ikäheimo TM;KIAS-Study Group
温度和湿度可能独立或共同增加流感感染的风险。我们研究了亚北极气候下温度、湿度的水平和下降与甲型和乙型流感病毒感染风险之间的关系。我们对军事训练期间因呼吸道症状就医的军人（n = 892）进行了病例交叉研究，通过PCR或血清学检测发现了66例甲型和乙型流感病例。获得了气象数据，例如发病前三天（危险期）以及发病前后两个参考期的环境温度和绝对湿度（AH）的平均和下降测量值。流感发作前的平均气温为-6.8±5.6°C，AH为3.1±1.3 g/m3。危险期间温度和 AH 的下降会增加流感的发生率，因此温度每降低 1°C 和 AH 每立方米减少 0.5 g，估计风险分别增加 11% [OR 1.11（1.03 至 1.20）] 和 58% [OR 1.58（1.28 至 1.96）]。流感感染的发生与发病前危险期内的平均温度[OR 1.10每1°C（95%置信区间1.02至1.19）]和AH[OR 1.25每g/m3（1.05至1.49）]呈正相关。我们的结果表明，在寒冷气候下，前三天内温度和湿度的下降而不是低温和湿度本身会增加流感发作的风险。
Both temperature and humidity may independently or jointly contribute to the risk of influenza infections. We examined the relations between the level and decrease of temperature, humidity and the risk of influenza A and B virus infections in a subarctic climate. We conducted a case-crossover study among military conscripts (n = 892) seeking medical attention due to respiratory symptoms during their military training period and identified 66 influenza A and B cases by PCR or serology. Meteorological data such as measures of average and decline in ambient temperature and absolute humidity (AH) during the three preceding days of the onset (hazard period) and two reference periods, prior and after the onset were obtained. The average temperature preceding the influenza onset was −6.8 ± 5.6°C and AH 3.1 ± 1.3 g/m3. A decrease in both temperature and AH during the hazard period increased the occurrence of influenza so that a 1°C decrease in temperature and 0.5 g decrease per m3 in AH increased the estimated risk by 11% [OR 1.11 (1.03 to 1.20)] and 58% [OR 1.58 (1.28 to 1.96)], respectively. The occurrence of influenza infections was positively associated with both the average temperature [OR 1.10 per 1°C (95% confidence interval 1.02 to 1.19)] and AH [OR 1.25 per g/m3 (1.05 to 1.49)] during the hazard period prior to onset. Our results demonstrate that a decrease rather than low temperature and humidity per se during the preceding three days increase the risk of influenza episodes in a cold climate.