Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum
Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum
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DOI：
10.1007/s11356-019-05122-0
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发表时间：
2019-06-01
影响因子：
5.8
通讯作者：
Pesce, Stephane
中科院分区：
文献类型：
--
作者：
Martin-Laurent, Fabrice;Topp, Edward;Pesce, Stephane
抗生素在人用和兽用药物中具有广泛的应用范围。大多数抗生素被设计用于药理学稳定性，在摄入后难以生物降解，并且可以在环境中持久存在。抗生素残留物已被检测为各种环境分区中的污染物，在这些环境分区中，抗生素残留物对人类和环境造成威胁，特别是在耐药性细菌的潜在出现和增殖方面。管理抗生素引起的环境风险的一个重要组成部分是了解土壤和水资源对其残留物的暴露。一个挑战是获得关于抗生素在生态系统中沿着土壤-水连续体的命运的知识，以及关于抗生素对负责至关重要的生态系统功能的环境微生物的附带影响的知识。在这方面，抗生素项目旨在研究磺胺类抗生素中的两种抗生素磺胺二甲嘧啶（SMZ）和磺胺甲恶唑（SMX）的环境归宿和影响。
Antibiotics have a wide application range in human and veterinary medicines. Being designed for pharmacological stability, most antibiotics are recalcitrant to biodegradation after ingestion and can be persistent in the environment. Antibiotic residues have been detected as contaminants in various environmental compartments where they cause human and environmental threats, notably with respect to the potential emergence and proliferation of antibiotic-resistant bacteria. An important component of managing environmental risk caused by antibiotics is to understand exposure of soil and water resources to their residues. One challenge is to gain knowledge on the fate of antibiotics in the ecosystem along the soil-water continuum, and on the collateral impact of antibiotics on environmental microorganisms responsible for crucially important ecosystem functions. In this context, the ANTIBIOTOX project aims at studying the environmental fate and impact of two antibiotics of the sulfonamide class of antibiotics, sulfamethazine (SMZ), and sulfamethoxazole (SMX).