Residual Effectiveness of Final Irrigation Regimens on Enteroccus faecalis-infected Root Canals
Residual Effectiveness of Final Irrigation Regimens on Enteroccus faecalis-infected Root Canals
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DOI：
10.1016/j.joen.2011.05.003
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发表时间：
2011-08-01
影响因子：
4.2
通讯作者：
Maria Ferrer-Luque, Carmen
中科院分区：
文献类型：
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作者：
Baca, Pilar;Luisa Mendoza-Llamas, Maria;Maria Ferrer-Luque, Carmen
导言：在相当长的一段时间内保持活性的最终冲洗液的应用是防止细菌再繁殖或消除根管治疗后残留细菌的一种策略。本研究的目的是评估四种最终冲洗方法在粪肠球菌污染的根管中的残留抗菌活性。方法：粪肠球菌生物膜在单根培养4周。经过化学机械处理后，采用4种灌溉方式：(1)EDTA-NaOCl组，17%EDTA+5.25%次氯酸钠(NaOCl)；(2)MA-NaOCl组，7%马来酸(MA)+5.25%NaOCl；(3)EDTA-CHX+CTR组，17%EDTA+2%洗必泰(CHX)+0.2%西曲胺(CTR)；(4)MA-CHX+CTR组，7%MA+2%CHX+0.2%CTR。样本收集了60天，以表示细菌生长的存在。用Fisher精确检验比较粪肠球菌无再生长的标本百分率。结果：用5.25%NaOCl作最后冲洗剂，第5天所有根管均获得阳性培养。EDTA-CHX+CTR组和MA-CHX+CTR组在末次灌水2%CHX+0.2%CTR时，60d无再生率分别为72.1%和66.8%。这些组之间在统计学上没有显著差异。结论：2%CHX+0.2%CTR的组合是一种有效的最终冲洗方案，因为其抗菌作用随着时间的推移而增加。(J Endod 2011；37：1121-1123)
Introduction: The application of a final irrigating solution that remains active over a fairly long period of time stands as one strategy for preventing bacterial recolonization or eliminating the bacteria that persist after root canal treatment. The aim of this study was to evaluate the residual antimicrobial activity of four final irrigation regimens in root canals contaminated with Enterococcus faecalis. Methods: Biofilms of E. faecalis were grown in uniradicular roots for 4 weeks. After preparing the roots chemomechanically, four final irrigation regimens were applied: (1) group EDTA-NaOCl, 17% EDTA followed by 5.25% sodium hypochlorite (NaOCl); (2) group MA-NaOCl, 7% maleic acid (MA) followed by 5.25% NaOCl; (3) group EDTA-CHX + CTR, 17% EDTA followed by 2% chlorhexidine (CHX) + 0.2% cetrimide (CTR); and (4) group MA-CHX + CTR, 7% MA followed by 2% CHX + 0.2% CTR. Samples were collected for 60 days to denote the presence of bacterial growth. The Fisher exact test was used to compare the percentages of specimens without E. faecalis regrowth. Results: All root canals in which the final irrigant was 5.25% NaOCl yielded positive cultures on the fifth day. Groups EDTA-CHX + CTR and MA-CHX + CTR with a final irrigation of 2% CHX + 0.2% CTR showed respective percentages of samples without regrowth of 72.1% and 66.8% at 60 days. There were no statistically significant differences between these groups. Conclusions: The combination of 2% CHX + 0.2% CTR would be an effective alternative final irrigation regimen given its antimicrobial action over time. (J Endod 2011;37:1121-1123)