Gestation-induced changes in lamotrigine pharmacokinetics:: A monotherapy study
Gestation-induced changes in lamotrigine pharmacokinetics:: A monotherapy study
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DOI：
10.1212/01.wnl.0000133213.10244.fd
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发表时间：
2004-08-10
期刊：
影响因子：
9.9
通讯作者：
Augustijn, P
中科院分区：
文献类型：
--
作者：
de Haan, GJ;Edelbroek, P;Augustijn, P
作者描述了12例使用拉莫三嗪（LTG）单药治疗的癫痫女性妊娠。9例妊娠的癫痫发作增加可能与LTG水平与剂量比逐渐下降至基线的40%有关。分娩后，LTG动力学迅速恢复到基线水平，导致一些妇女出现毒副作用。建议在妊娠前、妊娠期间和分娩后进行频繁的LTG水平监测和适当的剂量调整，特别是在接受LTG单药治疗的女性中。
The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level-to-dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjustments are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.