More than half of presumptive multidrug-resistant cases referred to a tuberculosis referral laboratory in the Tigray region of Ethiopia are multidrug resistant
More than half of presumptive multidrug-resistant cases referred to a tuberculosis referral laboratory in the Tigray region of Ethiopia are multidrug resistant
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DOI：
10.1016/j.ijmyco.2016.07.007
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发表时间：
2016-09-01
影响因子：
1.2
通讯作者：
Adane, Kelemework
中科院分区：
文献类型：
--
作者：
Tesfay, Kebede;Tesfay, Shinesh;Adane, Kelemework
目的/背景：编制耐多药结核病的流行病学数据对于评估抗结核药物耐药性的程度和趋势至关重要。本研究确定了埃塞俄比亚提格雷地区结核病转诊实验室转诊的推定耐多药病例中耐多药结核病的患病率。研究方法：对2013年1月至2014年8月期间提交给提格雷地区研究实验室进行MDR检测的262份培养阳性推定MDR-TB样本进行了回顾性横断面研究。使用结构化记录格式记录相关数据。结果如下：在262株结核分枝杆菌中，143株（54.6%）为MDR，28株（10.7%）仅对利福平耐药，19株（7.3%）仅对异烟肼耐药。新感染者耐多药结核病患病率为66.7%（8/12），既往治疗者耐多药结核病患病率为54.1%（97/179）。在测试的变量中，发现男性与耐多药结核病的发生有关（p= 0.003）。结论：提格雷地区研究实验室收到的推定MDR病例中有一半以上是MDR。在新感染和以前治疗的病例中，流行率都很高。因此，为了遏制耐多药结核病的出现和传播，必须加强结核病预防方法，加强直接观察短期治疗战略和实验室进行药物敏感性测试的能力。(C)2016年亚非分枝杆菌学会。制作和主办：Elsevier Ltd.
Objective/background: Generating epidemiological data on multidrug-resistant tuberculosis (MDR-TB) is essential to assess the magnitude and trends of anti-TB drug resistance. This study determined the prevalence of MDR-TB among presumptive MDR cases referred to a TB referral laboratory in the Tigray region of Ethiopia. Methods: A retrospective cross-sectional study was conducted on 262 culture-positive presumptive MDR-TB samples submitted to the Tigray Regional Research Laboratory for MDR testing between January 2013 and August 2014. Relevant data were recorded using a structured recording format. Results: Out of 262 Mycobacterium tuberculosis isolates, 143 (54.6%) were MDR, 28 (10.7%) were resistant to rifampicin only, and 19 (7.3%) were resistant to isoniazid only. The prevalence of MDR-TB among newly infected cases was 66.7% (8/12) and that among previously treated cases was 54.1% (97/179). Of the variables tested, being a male was found to be associated with the development of MDR-TB (p=.003). Conclusion: More than half of the presumptive MDR cases referred to the Tigray Regional Research Laboratory were MDR. The prevalence was high in both newly infected and previously treated cases. Hence, re-enforcing the TB prevention methods, and strengthening the directly observed treatment short-course (DOTS) strategy and the capacity of laboratories to undertake drug susceptibility testing (DST) in the region are imperative in order to curb the emergence and transmission of MDR-TB. (C) 2016 Asian-African Society for Mycobacteriology. Production and hosting by Elsevier Ltd.