Triggered Release from Liposomes through Magnetic Actuation of Iron Oxide Nanoparticle Containing Membranes
Triggered Release from Liposomes through Magnetic Actuation of Iron Oxide Nanoparticle Containing Membranes
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DOI：
10.1021/nl2001499
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发表时间：
2011-04-01
期刊：
影响因子：
10.8
通讯作者：
Reimhult, Erik
中科院分区：
文献类型：
--
作者：
Amstad, Esther;Kohlbrecher, Joachim;Reimhult, Erik
理想的纳米级药物递送载体允许在空间和时间上控制释放的剂量。我们证明，这可以通过隐形脂质体来实现，所述隐形脂质体包含用并入脂质膜中的棕榈基-硝基多巴单独稳定的自组装超顺磁性氧化铁纳米颗粒（NP）。交变磁场被用来通过局部加热膜来控制从这种囊泡中重复释放的货物的时间和剂量，这改变了膜的渗透性，而对环境没有重大影响。
The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time We demonstrate that this can be achieved by stealth liposomes comprising self assembled superpararnagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.