STAGING OF MEDIASTINAL NONSMALL CELL LUNG-CANCER WITH FDG PET, CT, AND FUSION IMAGES - PRELIMINARY PROSPECTIVE EVALUATION
STAGING OF MEDIASTINAL NONSMALL CELL LUNG-CANCER WITH FDG PET, CT, AND FUSION IMAGES - PRELIMINARY PROSPECTIVE EVALUATION
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DOI：
10.1148/radiology.191.2.8153308
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发表时间：
1994-05-01
期刊：
影响因子：
19.7
通讯作者：
ORRINGER, MB
中科院分区：
文献类型：
--
作者：
WAHL, RL;QUINT, LE;ORRINGER, MB
目得：评估使用正电子发射断层扫描（PET）与2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）在检测纵隔淋巴结转移nonsmall cell lung cancer.MATERIALS AND METHODS：一项前瞻性试验，比较FDG PET和胸部计算机断层扫描（CT）进行了23例新诊断或怀疑非小细胞肺癌。分别对CT、PET、CT + PET及融合图像进行盲法分析，并与病理结果进行比较。纵隔受累的患病率为41%。在纵隔疾病分期中，单独CT的敏感性为64%，特异性为44%，准确性为52%，而单独PET和融合图像的敏感性为82%，特异性为81%，准确性为81结论：FDG PET在肺癌患者纵隔疾病分期方面比CT更准确，似乎是临床首选的成像方法。设置.
PURPOSE: To evaluate use of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in detection of mediastinal lymph node metastases from nonsmall cell lung cancer.MATERIALS AND METHODS: A prospective trial to compare FDG PET and computed tomography (CT) of the thorax was performed in 23 patients with newly diagnosed or suspected non-small cell lung cancer. Blinded interpretations of CT alone, PET alone, CT and PET together, and fusion images were performed, and the results were compared with pathologic results.RESULTS: Nineteen of 23 patients had non-small cell lung cancer. Prevalence of mediastinal involvement was 41%. In staging disease in the mediastinum, CT alone was 64% sensitive, 44% specific, and 52% accurate, whereas PET alone and fusion images were 82% sensitive, 81% specific, and 81% accurate (P < .05).CONCLUSIONS: FDG PET was more accurate than CT in staging disease in the mediastinum in patients with lung cancer and appears to be the preferred imaging method in this clinical setting.