Incidence of asthma and its determinants among adults in Spain
Incidence of asthma and its determinants among adults in Spain
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DOI：
10.1164/ajrccm.164.7.2012143
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发表时间：
2001-10-01
影响因子：
24.7
通讯作者：
Antó, JM
中科院分区：
文献类型：
--
作者：
Basagaña, X;Sunyer, J;Antó, JM
目的是测量西班牙哮喘的发病率及其决定因素，西班牙哮喘的患病率为低至中等。1998-1999年对参加欧洲共同体呼吸健康调查（ECRHS）的受试者进行了随访（n = 1，640，85%的合格受试者）。研究对象于1991-1993年从普通人群中随机选择，年龄20 - 44岁。随访时间平均为6.75年（范围：5.3 - 7.9年）。哮喘定义为报告曾经患有哮喘。哮喘发病率为5.53（95%置信区间，4.28-7.16）/1,000人-年（女性6.88，男性4.04）。基线调查时支气管高反应性受试者（发病率比[IRR]，3.85）、抗梯牧草IgE阳性受试者（IRR，3.16）和女性（IRR，1.80）的发病率最高。这些结果在调整基线呼吸道症状后持续存在。与高血清总IgE无显著相关性（p < 0.2），特应性定义为对任何过敏原的反应性，吸烟，职业暴露或母亲哮喘。敏感性分析使用四种定义的人群在风险中产生的发病率从5.53到1.50不等。在基线时无自报哮喘或哮喘型症状的受试者人群中，支气管高反应性和对草的IgE反应性似乎是新发哮喘的主要决定因素。
The objective was to measure the incidence of asthma and its determinants in Spain, where the prevalence of asthma is low to medium. A follow-up of subjects participating in the European Community Respiratory Health Survey (ECRHS) was conducted in 1998-1999 (n = 1,640, 85% of those eligible). Subjects were ran om selected from the general population and were 20 to 44 yr old in 1991-1993. Time of follow-up was on average 6.75 yr (range, 5.3 to 7.9 yr). Asthma was defined as reporting ever having had asthma. The incidence of asthma was 5.53 (95% confidence interval, 4.28-7.16) per 1,000 person-years (6.88 in females, 4.04 in males). Incidence was highest in subjects who at the baseline survey had bronchial hyperresponsiveness (incidence rate ratio [IRR], 3.85), in those with positive IgE against timothy grass (IRR, 3.16), and in females (IRR, 1.80). These results persisted after adjusting for respiratory symptoms at baseline. There was no significant association (p < 0.2) with high total serum IgE, atopy defined by reactivity to any allergen, smoking, occupational exposure, or maternal asthma. A sensitivity analysis using four definitions of population at risk yielded incidence rates varying from 5.53 to 1.50. In this population of subjects without self-reported asthma or asthma-type symptoms at baseline, bronchial hyperresponsiveness and IgE reactivity to grass appeared as the main determinants of new asthma.