Detection and Molecular Characterization of Yellow Fever Virus, 2017, Brazil
Detection and Molecular Characterization of Yellow Fever Virus, 2017, Brazil
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DOI：
10.1007/s10393-018-1364-z
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发表时间：
2018-12-01
期刊：
影响因子：
2.5
通讯作者：
Trindade, G. S.
中科院分区：
文献类型：
--
作者：
Figueiredo, P. O.;Silva, A. T. S.;Trindade, G. S.
2016年底，巴西经历了前所未有的黄热病（YF）疫情。本研究描述了在暴发开始时收集的人类和非人类灵长类动物（NHP）样本的临床、分子和生态学方面。空间分布分析表明，人类和NHP病例之间有很强的重叠。通过分子分析，我们表明，这次暴发是由南美洲基因型1 YFV引起的森林起源，该病毒已在巴西流行。正如预期的那样，在疫苗接种覆盖率低的地区发现了病例群。我们的研究结果强调了动物监测和卫生服务同步的重要性，以识别新出现的YF病例，从而促进对弱势群体的更好应对。
At the end of 2016, Brazil experienced an unprecedented yellow fever (YF) outbreak. Clinical, molecular and ecological aspects of human and non-human primate (NHP) samples collected at the beginning of the outbreak are described in this study. Spatial distribution analyses demonstrated a strong overlap between human and NHP cases. Through molecular analyses, we showed that the outbreak had a sylvatic origin, caused by the South American genotype 1 YFV, which has already been shown to circulate in Brazil. As expected, the clusters of cases were identified in regions with a low vaccination coverage. Our findings highlight the importance of the synchronization of animal surveillance and health services to identify emerging YF cases, thereby promoting a better response to the vulnerable population.