Extremity cone-beam CT for evaluation of medial tibiofemoral osteoarthritis: Initial experience in imaging of the weight-bearing and non-weight-bearing knee.
Extremity cone-beam CT for evaluation of medial tibiofemoral osteoarthritis: Initial experience in imaging of the weight-bearing and non-weight-bearing knee.
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DOI：
10.1016/j.ejrad.2015.09.003
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发表时间：
2015-12
影响因子：
3.3
通讯作者：
Siewerdsen JH
中科院分区：
文献类型：
--
作者：
Thawait GK;Demehri S;AlMuhit A;Zbijweski W;Yorkston J;Del Grande F;Zikria B;Carrino JA;Siewerdsen JH
研究使用锥形束CT（CBCT）肢体成像系统对膝内侧间室骨关节炎（OA）患者进行非负重（NWB）和负重（WB）检查时关节间隙宽度（JSW）和关节突出（ME）的差异。在这项IRB批准的前瞻性研究中，获得了17例有OA症状的患者（11例女性，6例男性; 31-78岁，平均56岁）和18例无症状对照（0例女性，18例男性; 29-48岁，平均38.5岁）的知情同意书，这些患者入组了NWB和WB体位的CBCT检查。三名独立观察员测量内侧胫股JSW和ME。使用配对Wilcoxon符号秩和检验比较NWB和WB图像之间的测量值。OA受试者在NWB和WB扫描之间表现出统计学显著的JSW减少（平均值和，p = 0.016）和ME增加（平均值和，p = 0.018））。对于非OA受试者，NWB和WB检查之间的JSW和ME变化降低（平均值和;平均值和），无统计学显著性。使用Bland-Altman一致性限评价观察者间一致性，所有测量结果均具有良好的一致性（相关系数0.89-0.98）。在CBCT中进行NWB和WB检查的能力，与多排CT（MDCT）相比具有有利的剂量分布，并且图像质量足以进行关节间隙狭窄和关节挤压的形态分析，可以为OA诊断和治疗评估提供有价值的工具。
To investigate differences in joint space width (JSW) and meniscal extrusion (ME) between non-weight bearing (NWB) and weight bearing (WB) examinations of knee joints with medial compartment osteoarthritis (OA) using a cone-beam CT (CBCT) extremity imaging system. In this IRB approved prospective study, informed consent was obtained for 17 patients symptomatic for OA (11 F,6 M; 31–78 years, mean 56 years) and 18 asymptomatic controls (0 F,18 M; 29–48 years, mean 38.5 years) enrolled for CBCT exams in NWB and WB positions. Three independent observers measured medial tibiofemoral JSW and ME. Measurements were compared between NWB and WB images using paired Wilcoxon signed-rank sum test. OA subjects exhibited a statistically significant reduction in JSW between NWB and WB scans (average and , p = 0.016) and increase in ME (average and , p = 0.018)). For non-OA subjects, the change in JSW and ME between NWB and WB exams was reduced (average and ; average and ) and was not statistically significant. Inter-observer agreement was evaluated using Bland–Altman limits of agreement, with good agreement for all measurements (correlation coeffficient 0.89–0.98). The ability to conduct NWB and WB exams in CBCT with a dose profile that is favorable in comparison to multidetector CT (MDCT) and with image quality sufficient for morphological analysis of joint space narrowing and meniscal extrusion could provide a valuable tool for OA diagnosis and treatment assessment.