BENZALKONIUM CHLORIDE IN NASAL DECONGESTIVE SPRAYS HAS A LONG-LASTING ADVERSE EFFECT ON THE NASAL-MUCOSA OF HEALTHY-VOLUNTEERS
BENZALKONIUM CHLORIDE IN NASAL DECONGESTIVE SPRAYS HAS A LONG-LASTING ADVERSE EFFECT ON THE NASAL-MUCOSA OF HEALTHY-VOLUNTEERS
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DOI：
10.1111/j.1365-2222.1995.tb01070.x
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发表时间：
1995-05-01
影响因子：
6.1
通讯作者：
GRAF, P
中科院分区：
文献类型：
--
作者：
HALLEN, H;GRAF, P
20名健康志愿者参加了本研究，研究由羟甲唑啉鼻喷雾剂和苯扎氯铵组合或单独使用羟甲唑啉鼻喷雾剂组成的鼻充血缓解喷雾剂的长期作用。在本研究前三个月，参与者接受了为期4周的鼻减充血剂治疗。其中10例受试者接受了羟甲唑啉鼻喷雾剂（不含苯扎氯铵）治疗，10例接受了羟甲唑啉鼻喷雾剂（含苯扎氯铵）治疗。在一项双盲研究中，已接受羟甲唑啉鼻喷雾剂和苯扎氯铵治疗的受试者再次接受与之前相同的物质组合治疗，已单独接受羟甲唑啉鼻喷雾剂治疗的受试者也再次单独接受羟甲唑啉鼻喷雾剂治疗，但在这种情况下仅治疗10天。在治疗10天之前和之后研究三个变量，即鼻粘膜充血、鼻反应性和症状评分。结果发现，只有使用羟甲唑啉鼻喷雾剂和苯扎氯铵联合治疗的受试者的鼻阻塞增加，通过治疗10天后的症状评分和鼻粘膜肿胀测量进行估计。结论：由血管活性物质和苯扎氯铵组合组成的鼻减充血剂喷雾剂对鼻粘膜具有长期不良影响。
Twenty healthy volunteers participated in the present study on the long-term effects of a nasal decongestive spray composed of either a combination of oxymetazoline nasal spray and benzalkonium chloride or of oxymetazoline nasal spray alone. Three months before the present study the participants had undergone treatment with nasal decongestants for 4 weeks. Ten of the subjects had been treated with oxymetazoline nasal spray without bezalkonium chloride and 10 of them had been treated with oxymetazoline nasal spray with benzalkonium chloride. In a double-blind study the subjects who had been treated with oxymetazoline nasal spray and benzalkonium chloride were again treated with the same combination of substances as before, and the subjects who had been treated with oxymetazoline nasal spray alone were also treated again with oxymetazoline nasal spray alone, but on this occasion only for 10 days. Three variables were studied before and after the 10 days of treatment, i.e. nasal mucosa congestion, nasal reactivity and symptom scores. It was found that only the subjects who were treated with the combination of oxymetazoline nasal spray and benzalkonium chloride had increased nasal stuffiness, estimated by symptom scores and measurements of nasal mucosa swelling after 10 days of treatment. It is concluded that a nasal decongestant spray composed of a combination of vasoactive substance and benzalkonium chloride has a long-term adverse effect on the nasal mucosa.